期刊论文

Simultaneous Determination of Palmatine,Berberine and Jateorhizine in Jinji Capsules by QAMS

中文

中国药师

1008-049X

2014

9

1470-1472

10.3969/j.issn.1008-049X.2014.09.010

2013年湖南省科技厅一般项目（编号:2013KP0034）；

本校为第一机构

目的：建立金鸡胶囊中3个主要生物碱的一测多评含量测定方法。方法：以巴马汀为内参物,建立巴马汀与药根碱、小檗碱的相对校正因子,计算药根碱和小檗碱的含量,实现一测多评。采用外标法测定金鸡制剂中巴马汀、药根碱和小檗碱含量,Pearson相关系数法比较计算值和测定值的差异。结果：一测多评法的计算值和外标法测定值间无显著差异,试验所得的校正因子可信。结论：以外标法测定巴马汀,利用相对校正因子实现对药根碱和小檗碱成分含量测定可行。

Objective: To establish a quantitative analysis of multi-components by single marker ( QAMS ) for determining the three alkaloids in Jinji capsules. Methods:With the typical composition palmatine as the internal standard, the relative correction fac-tor ( RCF) between the palmatine and berberine or jateorhizine was respectively established, and the content of berberine and jateorhiz-ine was respectively calculated by QAMS. An external standard method was used to determine the three alkaloids, and the calculated values were compared with the estimated values by Pearson correlation coefficient. ...