期刊论文

中文

中国药师

1008-049X

2018

21

9

1570-1574

10.3969/j.issn.1008-049X.2018.09.016

湖南省教育厅科研基金项目（编号：12C0270、14C0740）） 湖南省自然科学基金项目（编号：11JJ3107） 大学生研究性学习和创新性实验计划项目（编号：校行教字[2012]13号）

本校为第一机构

目的:探索更昔洛韦替代阿昔洛韦组成的新目安眼用凝胶剂离体角膜渗透性能是否优于原目安眼用凝胶剂及市售制剂。方法:HPLC法测定更昔洛韦及阿昔洛韦含量并以此为指标,采用Franz扩散池法,进行离体角膜渗透性实验,建立数学模型,通过数学及统计学处理提取角膜渗透特性参数,比较新目安眼用凝胶剂与目安眼用凝胶剂渗透速度及渗透总量的差异。结果:新目安眼用凝胶剂角膜渗透特性优于目安眼用凝胶剂（角膜渗透速度是后者的3.452倍,角膜渗透数量是后者的1.832倍）,亦优于市售0.15%更昔洛韦眼用凝胶剂（角膜渗透速度是后者的2.029倍）,市售0.15%更昔洛韦眼用凝胶剂角膜渗透特性优于市售3%阿昔洛韦眼膏（角...

Objective： To study the permeability superiority in isolated cornea of new Mu＇an ophthalmic gel containing ganciclovir compared with that of Mu＇an ophthalmic gel containing acyclovir and commercially available preparations. Methods： The permeability test was performed on isolated cornea in Franz diffusion cells. The penetration amounts of ganciclovir and acyclovir were determined by HPLC. A mathematical model was established to calculate the extraction penetration parameters of isolated cornea through mathematical and statistical treatment....