The present study was supported by the National Natural Science Foundation of China (grant nos. 81201096 and 81503445) and Hunan Province Science and Technology program (grant nos. 2013SK3041 and 2016JJ2095).
机构署名：
本校为其他机构
院系归属：
中医学院
摘要：
Myeloid differentiation factor 88 (MyD88) and Toll or interleukin-1 receptor-domain-containing adaptor-inducing interferon-β (IFN-β) (TRIF) are two pivotal downstream adaptors of Toll-like receptors. Activation of MyD88 or TRIF signaling in cardiac immune pathology of severe inflammation negatively influences heart function. In the present study, severe septic cardiac injury was induced in C57BL/6 mice by cecum ligation and puncture (CLP). A total of 64 mice were divided randomly into the following four groups (n=16/group; 8 for observation o...
