Memory regulatory T cells in pregnancy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Zeyang;Zhang, Yanan;Kwak-Kim, Joanne;Wang, Wenjuan

通讯作者：

Wang, WJ;Kwak-Kim, J

作者机构：

[Chen, Zeyang] Qingdao Univ, Sch Med, Qingdao, Peoples R China.

[Chen, Zeyang; Wang, WJ; Wang, Wenjuan] Shanghai Jiao Tong Univ, Reprod Med Ctr, Xinhua Hosp, Sch Med, Shanghai, Peoples R China.

[Zhang, Yanan] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha, Peoples R China.

[Kwak-Kim, Joanne] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Clin Sci Dept, Reprod Med & Immunol,Obstet & Gynecol, Vernon Hills, IL 60064 USA.

[Kwak-Kim, Joanne] Rosalind Franklin Univ Med & Sci, Ctr Canc Cell Biol, Chicago Med Sch, Immunol & Infect, N Chicago, IL 60064 USA.

通讯机构：

[Kwak-Kim, J ] R

[Wang, WJ ] S

Shanghai Jiao Tong Univ, Reprod Med Ctr, Xinhua Hosp, Sch Med, Shanghai, Peoples R China.

Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Clin Sci Dept, Reprod Med & Immunol,Obstet & Gynecol, Vernon Hills, IL 60064 USA.

Rosalind Franklin Univ Med & Sci, Ctr Canc Cell Biol, Chicago Med Sch, Immunol & Infect, N Chicago, IL 60064 USA.

语种：

英文

关键词：

memory regulatory T cells;reproductive immunology;Pregnancy;Recurrent pregnancy loss;gestational diabetes mellitus;Preeclampsia

期刊：

Frontiers in Immunology

ISSN：

1664-3224

年：

2023

卷：

页码：

1209706

DOI：

10.3389/fimmu.2023.1209706

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

Pregnancy requires the process of maternal immune tolerance to semi-allogeneic embryos. In contrast, an overreactive maternal immune system to embryo-specific antigens is likely to result in the rejection of embryos while damaging the invading placenta, such that the likelihood of adverse pregnancy outcomes can be increased. Regulatory T cells (Tregs) are capable of suppressing excessive immune responses and regulating immune homeostasis. When stimulating Tregs, specific antigens will differentiate into memory Tregs with long-term survival and rapid and powerful immune regulatory ability. Immu...

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