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Is plasma cell-free DNA really a useful marker for diagnosis and treatment of trauma patients?

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成果类型:
期刊论文
作者:
Ren, Biqiong;Liu, Fengwei;Xu, Fei;He, Junyu;Zhu, Haowen;...
通讯作者:
Ren, BQ
作者机构:
[Ren, Biqiong; He, Junyu; Zhu, Haowen; Liu, Fengwei; Zou, Guoying; Xu, Fei] Hunan Univ Chinese Med, Dept Lab, Lab Peoples Hosp Hunan Prov 2, Changsha, Peoples R China.
[Ren, BQ] Hunan Univ Chinese Med, Dept Lab, Lab Peoples Hosp Hunan Prov 2, FURONG Rd 427 Changsha, Changsha, Peoples R China.
通讯机构:
[Ren, BQ ] H
Hunan Univ Chinese Med, Dept Lab, Lab Peoples Hosp Hunan Prov 2, FURONG Rd 427 Changsha, Changsha, Peoples R China.
语种:
英文
关键词:
Biomarker;Cell-free DNA;Diagnosis and treatment;Trauma
期刊:
Clinica Chimica Acta
ISSN:
0009-8981
年:
2013
卷:
424
页码:
109-113
基金类别:
This work was supported by a research grant from the Health Department of Hunan Province Foundation.
机构署名:
本校为第一且通讯机构
摘要:
Introduction: Plasma cell-free DNA (cfDNA) of trauma patients has been widely investigated, but it has not been resolved whether cfDNA can be used as a non-invasive, rapid and sensitive marker of injury. Here we evaluated serum cfDNA in patients after injury and assessed the relationship between cfDNA levels and clinical prognosis. Methods: Fifty-six trauma patients formed three groups (minor, moderate and severe) according to Injury Severity Score (ISS), 33 of these cases were also divided according to microbiological and clinical evidence of infection. Plasma cfDNA and other indices were mea...

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