Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao

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成果类型：

期刊论文

作者：

Deng, Meichun;Jiang, Liping;Luo, Xuan;Tao, Huai;Liang, Songping

通讯作者：

Deng, MC

作者机构：

[Deng, Meichun; Deng, MC] Cent South Univ, Sch Life Sci, Dept Biochem & Mol Biol, Changsha 410013, Hunan, Peoples R China.

[Jiang, Liping] Cent South Univ, Xiangya Sch Med, Dept Parasitol, Changsha 410013, Peoples R China.

[Luo, Xuan; Liang, Songping] Hunan Normal Univ, Coll Life Sci, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha 410081, Peoples R China.

[Tao, Huai] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Deng, MC ] C

Cent South Univ, Sch Life Sci, Dept Biochem & Mol Biol, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

jingzhaotoxin X;potassium channel blocking agent;potassium channel Kv4.2;potassium channel Kv4.3;sodium channel Nav1.5;sodium channel Nav1.7;spider venom;unclassified drug;voltage gated calcium channel;voltage gated potassium channel;amino acid sequence;animal experiment;animal model;Article;cation exchange;channel gating;Chilobrachys jingzhao;controlled study;disulfide bond;drug determination;drug effect;drug mechanism;drug potency;drug purification;embryo;human;human cell;intraplantar drug administration;mass spectrometry;mechanical hyperalgesia;molecular dynamics;motor performance;mouse;nonhuman;potassium current;reversed phase high performance liquid chromatography;rotarod test;tarantula

期刊：

JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

ISSN：

1678-9180

年：

2020

卷：

DOI：

10.1590/1678-9199-JVATITD-2019-0043

基金类别：

This work was supported by the National Natural Science Foundation of China (under contract Nos. 31672290, 31100764, 30901874 and 81503276), the Natural Science Foundation of Hunan Province, China (No. 2016JJ3180), the Valuable Instrument and Equipment Fund of Central South University (Nos. CSUZC2020043, CSUZC2019046).

机构署名：

本校为其他机构

院系归属：

医学院

中医学院

摘要：

Background: The tarantula Chilobrachys jingzhao is one of the largest venomous spiders in China. In previous studies, we purified and characterized at least eight peptides from C. jingzhao venom. In this report, we describe the purification and characterization of Jingzhaotoxin-X (JZTX-X), which selectively blocks Kv4.2 and Kv4.3 potassium channels. Methods: JZTX-X was purified using a combination of cation-exchange HPLC and reverse-phase HPLC. The amino-acid sequence was determined by automated Edman degradation and confirmed by mass spectrome...

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Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao

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