Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Deng, Meichun*;Jiang, Liping;Luo, Xuan;Tao, Huai;Liang, Songping

通讯作者：

Deng, Meichun

作者机构：

[Deng, Meichun] Cent South Univ, Sch Life Sci, Dept Biochem & Mol Biol, Changsha 410013, Hunan, Peoples R China.

[Jiang, Liping] Cent South Univ, Xiangya Sch Med, Dept Parasitol, Changsha 410013, Peoples R China.

[Luo, Xuan; Liang, Songping] Hunan Normal Univ, Coll Life Sci, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha 410081, Peoples R China.

[Tao, Huai] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Deng, Meichun] C

Cent South Univ, Sch Life Sci, Dept Biochem & Mol Biol, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

Tarantula toxin;Potassium channels;Kv4;Patch-clamp;Pain

期刊：

Journal of Venomous Animals and Toxins Including Tropical Diseases

ISSN：

1678-9199

年：

2020

卷：

DOI：

10.1590/1678-9199-JVATITD-2019-0043

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31672290, 31100764, 30901874, 81503276]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [2016JJ3180]; Valuable Instrument and Equipment Fund of Central South University [CSUZC2020043, CSUZC2019046]

机构署名：

本校为其他机构

院系归属：

医学院

中医学院

摘要：

Background: The tarantula Chilobrachys jingzhao is one of the largest venomous spiders in China. In previous studies, we purified and characterized at least eight peptides from C. jingzhao venom. In this report, we describe the purification and characterization of Jingzhaotoxin-X (JZTX-X), which selectively blocks Kv4.2 and Kv4.3 potassium channels. Methods: JZTX-X was purified using a combination of cation-exchange HPLC and reverse-phase HPLC. The amino-acid sequence was determined by automated Edman degradation and confirmed by mass spectrome...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问