期刊论文

Effect of electroacupuncture at Ganshu(BL 18)and Shenshu(BL 23)on the expression of EphB2 protein in cortex around cerebral infracted area of rat

Tie-lang Li

英文

针灸推拿医学：英文版

1672-3597

2017

15

1

14-21

10.1007/s11726-017-0968-0

supported by the Open Fund for Colleges and Universities Innovation Platform of Hunan Province,No.14K070； Key Project of Hunan Province Administration of Traditional Chinese Medicine,No.201310； Innovation Fund Project for Graduate Student of Hunan Province,No.CX2014B360~~；

本校为第一且通讯机构

Objective:To observe the effect of electroacupuncture(EA)on the expression of erythropoie-tin-producing hepatocyte receptor B2(EphB2)in the cortex around the infracted area of middle cerebral artery occlusion(MCAO)rats at different timing,and to reveal the possible mechanism of acupuncture in the treatment of cerebral ischemia.Methods:A total of 180 male Sprague-Dawley(SD)rats were randomly divided into a sham operation group,a model group,an acupoint group and a non-acupoint group,with 45 rats in each group.Rats in each group were further divided into three subgroups:postoperative 3 d,postope...

目的:观察电针对大脑中动脉梗塞（MCAO）模型大鼠不同时间点梗死灶周围皮层促红细胞生成素产生肝细胞受体B2（Eph B2）表达的影响,以期揭示针刺治疗脑缺血病的可能作用机制。方法:将180只雄性SpragueDawley（SD）大鼠随机分为假手术组、模型组、穴位组和非穴位组,每组45只;各组又分为术后3 d,14 d及21 d三个亚组,每组15只。采用改良线栓法复制MCAO大鼠模型,采用神经功能评分、2,3,5-氯化三苯基四氮唑（TTC）染色、免疫组化法、免疫荧光双标法及Western blot法进行相应指标检测。结果:大鼠术后神经功能缺损在3 d时最明显,之后随着时间延长逐渐改善,其中以穴位组更显著（P