期刊论文

Effects of different doses of ginger-partitioned moxibustion on trefoil factor 1, mucin 5AC and epidermal growth factor receptor in rats with spleen deficiency syndrome

Zhan Yi

英文

针灸推拿医学：英文版

1672-3597

2018

16

1

1-7

10.1007/s11726-018-1015-5

This work was supported by Fund Project of Hunan Province Education Office (湖南省教育厅科研计划项目, No.13C685); Graduate Student Research Innovation Project of Hunan Province (湖南省研究生科研创新项目, No. CX2016B351); Undergraduate Student Research Innovation Project of Hunan Province (湖南省大学生科研 创新项目, No. 201409060207).

本校为第一且通讯机构

Objective: To observe the effects of different doses of ginger-partitioned moxibustion on serum trefoil factor 1 (TFF1) and mucin 5AC (MUC5AC) levels, as well as the expression of epidermal growth factor receptor (EGFR) in gastric mucosa of rats with spleen deficiency syndrome, therefore, to explore the possible mechanism and the dose-effect characteristics of ginger-partitioned moxibustion in spleen deficiency syndrome. Methods: Seventy-five SPF grade Sprague-Dawley (SD) rats were randomly divided into a blank control group (group A), a model ...

目的:观察不同灸量隔姜灸对脾虚证大鼠血清三叶因子1(TFF1)和粘蛋白5AC(MUC5AC)含量, 以及胃黏膜表皮生长因子受体(EGFR)蛋白表达的影响, 探讨隔姜灸治疗脾虚证的可能作用机制及量效特征。方法:将75只SPF级Sprague-Dawley(SD)大鼠按随机数字表法分为空白对照组(A组)、模型组(B组)、隔姜灸3壮组(C1组)、隔姜灸6壮组(C2组)和隔姜灸9壮组(C3组), 每组15只。除A组外, 其余各组大鼠采用200%的大黄浓缩液4 ℃灌胃制作脾虚证大鼠模型。造模成功后, B组大鼠不予治疗; C1、C2和C3组大鼠分别接受3壮、6壮和9壮隔姜灸足三里和中脘治疗, 连续治疗8 d。观察大鼠一般症状评分, 采用酶联免疫吸附法(ELISA)检测血...