Objective: To observe the influence of pressing force and time on the thermal effect of An-pressing manipulation. Methods: Eight healthy volunteers were recruited to receive An-pressing manipulation at Xinshu (BL 15) on the right side. The pressing force and time were both divided into five levels: the force described as extremely mild, mild, moderate, strong and extremely strong and time given by 2.5 min, 5.0 min, 7.5 min, 10.0 min and 15.0 min. The real-time change in local acupoint temperature as well as the change during 1.0-15.0 min after ...