期刊论文

Effect of point-moxibustion on ghrelin and GHSR-1a expressions in lateral septal nucleus of rats with diabetic gastroparesis

Xiao-rong Chang<&wdkj&>Jing Li

英文

针灸推拿医学：英文版

1672-3597

2018

16

4

216-222

10.1007/s11726-018-1053-z

?The authors declared that there was no potential conflict of int? erestin thisarticle. Ac? knowledgments ?This work was supported by National Basic Research Program ? of China (973 Program, 国家重点基础研究发展 计划项目? , No. 2015CB554502); National Natural Science Foundation ? of China (国家自然科学基金项目, No. 81574082, ? No. 81774431); Hunan Provincial Natural S?cience Foundation of China (湖南省自然科学基金项目, N? o. 2018JJ2295); Fund Project of Hunan Province Education? Office (湖南省教育厅科学研究项目, No. 14B129); ? Hunan Provincial Project of Scientific and T?echnological Innovation Platform and Talent Plan: Academician ? Shi Xue-min Expert Workstation (湖南省科 No.2017RS3052); 技创新平台与人才计划项目? State ClinicalKey Specialty of Tuina -石学敏院士专家工作站, Departm? ent of Yueyang Hostpital Affiliated to Hunan Univers? ity of Chinese Medicine (湖南中医药大学附属岳 阳医院推拿科国家临床重点专科); Tuina Key Discipline of State Administration of Traditional Chinese Medicine (推拿学国家中医药管理局重点学科).

本校为第一且通讯机构

Objective: To observe the effect of point-moxibustion on gastrointestinal motility, mRNA and protein expressions of ghrelin and growth hormone secretagogue receptor 1a (GHSR-1a) in lateral septal nucleus of rats with diabetic gastroparesis (DGP), and to investigate the central regulatory mechanism of DGP treatment with point-moxibustion. Methods: Forty SPF-grade Sprague-Dawley (SD) rats were randomly divided into a blank group, a model group, an electroacupuncture (EA) group and a point-moxibustion group, with 10 rats in each group. A DGP rat m...

目的:观察点灸对糖尿病胃轻瘫(DGP)大鼠胃肠运动、外侧隔核胃促生长素和生长激素促分泌受体1a (GHSR-1a) mRNA及蛋白表达的影响,探讨点灸治疗DGP的中枢调节机制.方法:将40只SPF级Sprague-Dawley (SD)大鼠按随机数字表法分为空白组、模型组、电针组和点灸组,每组10只.模型组、电针组和点灸组采用腹腔注射2%的链脲佐菌素(STZ)配合8周的不规律高糖高脂饮食建立DGP大鼠模型,空白组腹腔注射0.1 mmoL/L (pH 4.5)的柠檬酸-柠檬酸钠缓冲液配合8周普通喂养.8周后电针组采用电针足三里、梁门和三阴交治疗;点灸组采用点灸足三里、梁门和三阴交治疗,连续15 d;空白组和模型组予以捆绑对照,不予治疗.治疗后测定...