期刊论文

Regulatory effect of herbal cake-partitioned moxibustion on cholesterol reverse transport nuclear receptor LXRα in rabbits with atherosclerosis

Chang, XR;Shen, J

英文

针灸推拿医学：英文版

1672-3597

2019

17

1

1-8

10.1007/s11726-019-1087-x

? The authors declared that there was no potential conflict of int? erestin thisarticle. Ac? knowledgments ? This work was supported by National Natural Science Foundation ? of China ( 国 家 自 然 科 学 基 金 项 目 , No. ? 81874509, No. 81704182, No. 81403486); Graduate S?tudent Research Innovation Project of Hunan Province (?湖南省研究生科研创新项目, No. CX2017B430); Yifang Graduate ? Student Research Innovation Project of Hunan Universit? y of Chinese Medicine(湖南中医药大学一方研 究? 生科研创新课题项目, No. YF201716); Hunan Provincial ? Natural Science Youth Fund (湖南省自然科学 青年基金? , No. 2018JJ3397). S?tatement of Human and Animal Rights

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Objective: To observe the effect of herbal cake-partitioned moxibustion on liver X receptor alpha (LXRα) in rabbits with atherosclerosis. Methods: Thirty-six male New Zealand rabbits were randomly divided into a normal group, a model group, a herbal cake-partitioned moxibustion group and a simvastatin group according to the random number table method, with 9 rabbits in each group. Rabbits in the model group, the herbal cake-partitioned moxibustion group and the simvastatin group were modeled by high fat feeding method which took 12 weeks. Afte...

目的:观察隔药饼灸对动脉粥样硬化兔胆固醇逆转运肝X受体α(LXRα)的影响.方法:将36只雄性新西兰兔按随机数字表法随机分为正常组、模型组、隔药饼灸组和辛伐他汀组,每组9只.模型组、隔药饼灸组和辛伐他汀组采用高脂饲养法造模,共12周.验证造模成功后,正常组不予治疗,模型组予以捆绑,隔药饼灸组予以隔药饼灸治疗,辛伐他汀组予以辛伐他汀治疗,共治疗4周.实验结束后取主动脉及肝脏观察其病理形态变化,取血清及肝脏检测脂质水平,以蛋白质印迹法(WB)和实时荧光定量聚合酶链反应(RT-qPCR)法分别检测LXRα蛋白及 mRNA表达水平.结果:与正常组比较,模型组主动脉结构紊乱,管壁粗糙增厚,内膜不光滑,血管平...