期刊论文

Effect of herbal cake-partitioned moxibustion on Leptin/JAK2/STAT3 in lipid-lowering pathway of hyperlipidemia rabbits

Xiao-rong Chang

英文

针灸推拿医学：英文版

1672-3597

2019

17

6

371-382

10.1007/s11726-019-1139-2

This work was supported by Hunan Province College Innovation Open-end Fund Project (湖南省高校创新平台开放基金项目, No. 16K068); 2017 Scientific and Research Innovative Project for Postgraduate Students of Hunan Province (2017 年湖南省研究生科研创新项目, No. CX2017B431).

本校为第一且通讯机构

Objective: To observe the lipid-lowering effect of different transdermal absorption enhancers applied to the herbal cake-partitioned moxibustion in hyperlipidemia model rabbits, and to explore the possible mechanism. Methods: Forty New-Zealand rabbits were randomly divided into 5 groups using the random number table method, with 8 rats in each group. Rabbits in the blank group were fed routinely with normal diet; rabbits in the other groups were fed with high-fat diet for 12 weeks to establish the hyperlipidemia model. Rabbits in the blank and ...

目的:观察不同促透剂运用于隔药饼灸对高脂模型兔降脂效果的影响, 探讨其可能机制.方法:将40只新西兰兔按随机数字表法随机分成5组, 每组8只.空白组正常喂养普通饲料; 其余组高脂饲料喂养12周, 复制高脂模型.空白组和模型组不治疗.无促透剂组成模后采用不加促透剂药饼施灸; 氮酮组和冰片组分别将氮酮和冰片用于药饼中, 进行隔药饼灸.治疗4周后, 分离血清进行酶联免疫吸附测定(ELISA), 分离肝脏组织进行免疫组化、定量聚合酶链式反应(qPCR)和蛋白免疫印迹(WB)检测.结果:血清ELISA检测结果显示, 与空白组比较, 模型组Leptin显著下降(P＜0.05); 与模型组比较, 无促透剂组、氮酮组和冰片组Leptin显著...