group were significantly higher than those in the normal ?ethotrexate is recognized as the option for the group ?PA䐃? ? 缃唀 shuagtgetshtien g hitgh m?NA treatment of ?A ? but its long ?term adverse reactions are expressions of c 爀IAP ? and c ?IAP in the model grorueplatively significant ? In our experimental results ? may be the cause of synovial hyperplasia and joint although methotrexate was better than EA in improving swelling ? The results of HE staining showed that the EA the swelling of toe and AI score 唀 in terms of the body group had mild hyperplasia of synovium 唀 while the weight ? the effect of EA was slightly better than that of synovitis and cartilage destruction were not obvious ? methotrexate 唀 which may be related to adverse drug suggesting that the pathological morphology of the EA reactions ? The results ofisthstudy indicated that EA group was improved 堀 The m?NA expressions of c ?IAP ? should be effective in the treatment of ?A ? and it is easy and c 爀IAP in the synovial tissues of the EA group were to operate and has no adverse reactions ? EA can be significantly lower than those in the model group used as a practicable method for the treatment of ?A ?PA? ????唀 suggesting that EA down?regulaatnedd detsheerv esfurther study堀 expressions of c 爀IAP and c ?IAP in the synovial tissues ? thereby achieving inhibition of synovial hyperplasia and reducing joint swelling ? In ?hinese medicine ? ?A falls under the category of ?i ?impediment syndrome ? Its etiological factors can be external or internal 堀 Internally 唀 this condition is mainly caused by deficiency of the liver and kidney and general This work was supported by Youth Fund of National deficiency of qi and blood 堀 External pathogenic factors Natural Science Foundation of China (国家自然科学基金 include wind 唀 cold and damp heat 堀 In summary 唀 the root青年基金项目, No. 81303048, No. 81804204). cause of ?A is deficiency ? whereas its manifestations Statement of Human and Animal Rights appear excessive?爃???Th?is actually matches with the understanding of modern medicine P a long 爁騁?rm autoimmune and inflammatory disorder ? The treatment principles of ?A vary from doctor to doctor ? but they all agree with a general treatment principle of strengthening the healthy qi to eliminate pathogenic factors?????In the ancient and modern literatures and researches on acupuncture treatment of Autoimmune arthritides,rheumatoid arthritis, psoriatic Arvikar SL, CrowleyJT, Sulka KB, Steere AC. ?A ? the choice of acupoints mainly follows local point arthritis, or peripheral spondyloarthritis following lyme selection ? combined with special acupoints that disease. Arthritis Rheumatol, 2017, 69(1): 194-202. regulate immune function 唀 such as ?usanli 縀ST 缃唀 [2]Qihai Li H, Wan A. Apoptosis of rheumatoid arthritis fibroblast- ??? ? ? ? Guanyuan ? ?? ? ? ? ?ingmen ?Gl?ike s?yno?vio?cyteGs:a npsohssuible roles of nitric oxide and the 縀ᄀL ? 缀 and Shenshu ??L ? 缃堀 In general 唀 it rtheifolerecdtosx tihne1. Mediators Inflamm, 2013, 2013: 953462. treatment principles of strengthening the body [3] Shi DL, Shi GR, Xie J, Du XZ, Yang H. MicroRNA-27a resistance and dispelling exogenous pathogen to relieve inhibits cell migration and invasion of fibroblast-like the symptoms 堀 In this experiment 唀 Ashi acupoints 唀 synoviocytes by targeting follistatin-like protein 1 in ?usanli ?ST ? ? ?and Guanyuan ??? ? ? ?rheumwhaictoid arthrh canitis. Mol Cells, 2016, 39(8):611-618. enhance the immune function of the body ? were [4] Liu XZ, Fan J, Qi K, Liu SP, Xu WD, Gao Y, Gu XD, Li J, selected 堀 Among them 唀 Acsuhpi oaints directly work on promotes apoptosis and inhibits inflammatorycytokineBai CG, Shi YQ, Zhang LL, Zhao DB. Dishevelled2 the affected region to make the local qi and blood secretion in rheumatoid arthritis fibroblast-like smooth by adjusting local meridians ? ?usanli 縀ST ? and synoviocytes through crosstalk with the NF-κB pathway. Guanyuan 縀?? ? 缀 can benefit qi and solidify the body 唀 Oncotarget, 2017, 8(8): 12649-12663. adjust the immune function 唀 and resist the evil outside ? [5] Stanford SM, Maestre MF, Campbell AM, Bartok B, and produce the therapeutic effect of eliminating Kiosses WB, Boyle DL, Arnett HA, Mustelin T, Firestein pathogen and strengthening healthy qi??堀 ?? GS, Bottini N. Protein tyrosine phosphatase expression Furthermore ? in this experiment ? EA andprofileofrheumatoidarthritis fibroblast-likesynoviocytes: methotrexate both improved the toe swelling ? AI score ? a novel role of SH2 domain-containing phosphatase 2 as a and m?NA expressions of c ?IAP ? and c ?IAP ? in synovialmodulator of invasion and survival. Arthritis Rheum, 2013, tissues of ?A rats 唀 methotrexate was better than EA in [6]TokunagaF, Sakata S, Saeki Y, Satomi Y, Kirisako T,65(5): 1171-1180. suppressing the expressions of c 爀IAP ? and c ?IAP ? Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, m?NAs ?PA? ????堀 This difference suggested that EA and Yamamoto M, Akira S, Takao T, Tanaka K, Iwai K. methotrexate may have different mechanisms in Involvement oflinear polyubiquitylation ofNEMO in treating ?A ? The specific mechanism remains to be NF-kappaB activation. Nat Cell Biol, 2009, 11(2): 123-132. further studied ?
