期刊论文

电针对原发性痛经大鼠子宫组织前列腺素F2α、环氧化酶2和核因子κB的影响

Biao Tang

英文

针灸推拿医学：英文版

1672-3597

2020

18

6

418-424

10.1007/s11726-020-1209-5

国家自然科学基金项目,No.82004490 湖南省研究生科研创新项目,No.CX2018B515 湖南中医药大学中医学一流学科开放基金,No.2018ZYX05 湖南中医药大学“十三五”一级学科基础医学建设项目,No.06.

本校为第一且通讯机构

Objective: To observe the effects of electroacupuncture (EA) on uterine prostaglandin F2α (PGF2α), cyclooxygenase 2 (COX-2) and nuclear factor κB (NF-κB) in rats with primary dysmenorrhea (PD) and to discuss the possible mechanism in EA intervening PD. Methods: Forty Sprague-Dawley female rats were randomly divided into a blank group, a model group, an EA group and an ibuprofen group, with 10 rats in each group. The PD model was established using estradiol benzoate combined with oxytocin in the model group, EA group and ibuprofen group. At ...

目的:观察电针对原发性痛经(PD)大鼠子宫组织前列腺素F2α(PGF2α)、环氧化酶2(COX-2)和核因子κB(NF-κB)的影响,探讨电针干预PD的可能机制.方法:将40只Sprague-Dawley雌性大鼠随机分为正常组、模型组、电针组和布洛芬组,每组10只.模型组、电针组和布洛芬组采用苯甲酸雌二醇联合缩宫素建立PD大鼠模型.造模同时,电针组大鼠给予电针关元和三阴交治疗,每日1次,每次20 min,连续10 d;布洛芬组给予布洛芬灌胃干预,每日1次,连续10 d;正常组和模型组给予等量的生理盐水灌胃,每日1次,连续10 d.于第11天比较各组大鼠30 min内扭体次数;酶联免疫吸附测定法检测子宫匀浆上清液中PGF2α水平;Western blot检测...