会议论文

中文

2013

63-64

世界中医药学会联合会中药药剂专业委员会、中华中医药学会中药制剂分会学术年会暨“江中杯”中药制剂创新与发展论坛

世界中医药学会联合会中药药剂专业委员会、中华中医药学会中药制剂分会学术年会暨“江中杯”中药制剂创新与发展论坛论文集

2012-11-01

南昌

中国药理学会

世界中医药学会联合会中药药剂专业委员会<&wdkj&>中华中医药学会中药制剂分会

本校为第一机构

目的:创立中药复方多成分的网络药效动力学数学模型及参数测算方法。方法:利用网络动力学原理建模并结合拉氏变换与线性代数求得方程的通解及参数测算方法。结果:建立了中药复方网络药效动力学的线性数学模型,其特征为e的幂指数多项式;各节点的平衡常数可通过建立AUC与节点初始量的线性方程求得,注射与口服均有相似的体内节点平衡常数求算方法,但口服还可求出吸收平衡常数。据此可进行中药复方的量-比、量-时、量-效网

　　AIM: To establish the mathematical model and determination method of network pharmacodynamics for Chinese Materia Medica Formula.METHODS: By network pharmacokinetic principle, combining with the Laplace Transform, as well as Linear Algebra, the general solution for equation of network pharmacodynamics were obtained and their parameters were analysed.RESULTS: The CMMs fomula network pharmacodynamic model was established with e power polynomial.The equilibrium constants of each nodals in network were obtained by solving linear equation establ...