Liposomal Silybin Improves Glucose and Lipid Metabolisms in Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease via AMPK/TGF-β1/Smad Signaling

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cai, Jialuo;Zhu, Yilin;Li, Xiaoping;Deng, Guiming;Han, Yuanshan;...

通讯作者：

Xia, XH

作者机构：

[Xia, Xinhua; Cai, Jialuo; Xia, XH] Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Cai, Jialuo; Li, Xiaoping] Hunan Univ Chinese Med, Hosp 1, Prevent Treatment Dis Ctr, Changsha, Hunan, Peoples R China.

[Zhu, Yilin] Hunan Univ Chinese Med, Grad Sch, Changsha, Hunan, Peoples R China.

[Han, Yuanshan; Deng, Guiming] Hunan Univ Chinese Med, Hosp 1, Sci Res Sect, Changsha, Hunan, Peoples R China.

[Yuan, Feiyun] Hunan Univ Chinese Med, Lib, Changsha, Hunan, Peoples R China.

通讯机构：

[Xia, XH ] H

Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

diabetes mellitus;glycolipid metabolism;liposomes;non-alcoholic fatty liver disease;silybin

期刊：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

ISSN：

0040-8727

年：

2023

卷：

261

期：

页码：

257-265

DOI：

10.1620/tjem.2023.J050

基金类别：

Hunan Clinical Medical Technology Innovation and Guidance Project, China [2021SK51408]; Hunan Traditional Chinese Medicine Research Program, China [D2022091]; Key Discipline Project on Chinese Parmacology of Hunan University of Chinese Medicine [202302]; Scientific Research Program of Hunan Provincial Health Commission, China

机构署名：

本校为第一机构

院系归属：

第一中医临床学院

药学院

研究生院

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摘要：

Improving hepatic glucose and lipid metabolisms is an important strategy to treat type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease (T2DM-NAFLD). Silybin (SLB) has the potential hepatoprotection, while its oral bioavailability is poor. This study aims to investigate the functional role and mechanism of liposomal SLB in modulating glucose/lipid metabolism in T2DM-NAFLD. SLB was prepared by thin film dispersion method and characterized using dynamic light scattering, scanning electron microscope, high performance liquid ...

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Liposomal Silybin Improves Glucose and Lipid Metabolisms in Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease via AMPK/TGF-β1/Smad Signaling

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