期刊论文

Shang, Yi;Huang, Sanwen

英文

Nature Plants

2055-026X

2016

2

12

16183

10.1038/nplants.2016.183

National Key R & D Program for Crop Breeding [2016YFD0100307]; National Science Fund for Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [31225025]; National Program on Key Basic Research Projects in China (the 973 Program)National Basic Research Program of China [2012CB113900]; leading talents of Guangdong province Program [00201515]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31322047, 31401886, 31101550, 31672171]; Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences (CAAS-ASTIP-IVFCAAS); Chinese Ministry of Finance [1251610601001]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2014M550902]; Discovery Grant from National Science and Engineering Research Council of Canada (NSERC); Canada Research Chair programCanada Research Chairs; UK Biotechnological and Biological Sciences Research Council Institute Strategic Programme Grant 'Understanding and Exploiting Plant and Microbial Metabolism' [BB/J004561/1]; John Innes Foundation; Genomes to Natural Products National Institutes of Health Programme [U01GM110699]; Shenzhen Municipal Government; Dapeng District Government; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [U01GM110699, U01GM110699, U01GM110699, U01GM110699, U01GM110699, U01GM110699] Funding Source: NIH RePORTER; Biotechnology and Biological Sciences Research CouncilUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BBS/E/J/000CA527, BBS/E/J/000CA533, BBS/E/J/00000614, BB/L014130/1] Funding Source: researchfish; Engineering and Physical Sciences Research CouncilUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/K034359/1] Funding Source: researchfish

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Differentiation of secondary metabolite profiles in closely related plant species provides clues for unravelling biosynthetic pathways and regulatory circuits, an area that is still underinvestigated. Cucurbitacins, a group of bitter and highly oxygenated tetracyclic triterpenes, are mainly produced by the plant family Cucurbitaceae. These compounds have similar structures, but differ in their antitumour activities and ecophysiological roles. By comparative analyses of the genomes of cucumber, melon and watermelon, we uncovered conserved synten...