期刊论文

Establishment of a risk score model for laryngeal squamous cell carcinoma based on immune hub genes

He, Y.

中文

实用肿瘤杂志

1001-1692

2022

37

1

44-49

10.13267/j.cnki.syzlzz.2022.008

国家自然科学基金（81874408,81973914）； 湖南省自然科学基金（2019JJ40216,2020JJ5419）； 中医药防治眼耳鼻咽喉疾病湖南省重点实验室开放基金（2018YZD04）； 湖南中医药大学基础医学一流学科开放基金（2018JCYX08）；

本校为第一且通讯机构

目的 筛选喉鳞状细胞癌(laryngeal squamous cell carcinoma,LSCC)预后相关免疫核心基因并构建预后风险评分模型.方法 利用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库中LSCC转录组测序信息,筛选差异表达基因,并与已知免疫相关基因取交集,筛选LSCC中预后相关免疫核心基因.利用单因素Cox回归构建风险评分模型并采用Kaplan-Meier法验证风险评分模型与LSCC患者预后的关系,同时绘制受试者工作特征(receiver operating characteristic,ROC)曲线验证该模型准确度.结果 LSCC组织和癌旁组织中共有6800个差异表达基因,通过单因素Cox分析并与已知免疫相关基因取交集,从差异表达基因中筛选出34个预...

Objective: To screen the immune hub genes related to the prognosis of laryngeal squamous cell carcinoma (LSCC) and to construct a prognostic risk score model. Methods: LSCC transcriptome sequencing information in The Cancer Genome Atlas (TCGA) database was used to screen differentially expressed genes, and the intersection of known immune-related genes was used to screen the prognostic immune hub genes in LSCC. Univariate Cox regression was used to construct the risk score model, and Kaplan-Meier method was used to verify the relationship betwe...