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Production of ρ-Hydroxyacetophenone by Engineered Escherichia coli Heterologously Expressing 1-(4-Hydroxyphenyl)-Ethanol Dehydrogenase.

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成果类型:
期刊论文
作者:
Wu, Wenmei;Yuan, Xiwei;Gao, Xin;Tan, Chaoyang;Li, Shunxiang;...
作者机构:
[Gao, Xin; Yuan, Xiwei; Tan, Chaoyang; Xu, Dehong; Wu, Wenmei] Biological Engineering Laboratory, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China
[Xu, Dehong; Li, Shunxiang] Hunan Engineering Technology Research Center for Bioactive Substance Discovery of Chinese Medicine, Changsha, Hunan 410208, P.R. China
[Xu, Dehong; Li, Shunxiang] Hunan Province Sino-US International Joint Research Center for Therapeutic Drugs of Senile Degenerative Diseases, Changsha, Hunan 410208, P.R. China
语种:
英文
关键词:
1-(4-hydroxyphenyl)-ethanol dehydrogenase;Escherichia coli;biotransformation;ρ-Hydroxyacetophenone
期刊:
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
ISSN:
1017-7825
年:
2024
卷:
34
期:
2
页码:
467-475
机构署名:
本校为第一机构
院系归属:
药学院
摘要:
ρ-Hydroxyacetophenone is an important and versatile compound that has been widely used in medicine, cosmetics, new materials, and other fields. At present, there are two ways to obtain ρ-hydroxyacetophenone. One is to extract it from plants, such as Artemisia capillaris Thunb and Cynanchum otophyllum Schneid, and the other is to synthesize it by using chemical methods. Of these two methods, the second is the main one, although it has problems, such as flammable and explosive reagents, difficult separation of by-products, and harsh reaction co...

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