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Dracocephalum moldavica attenuates scopolamine-induced cognitive impairment through activation of hippocampal ERK-CREB signaling in mice

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成果类型:
期刊论文
作者:
Deepa, Ponnuvel;Bae, Ho Jung;Park, Hyeon-Bae;Kim, So-Yeon;Choi, Ji Woong;...
通讯作者:
Park, Se Jin;Ryu, Jong Hoon
作者机构:
[Kim, So-Yeon; Deepa, Ponnuvel; Park, Se Jin; Park, Hyeon-Bae] Kangwon Natl Univ, Sch Nat Resources & Environm Sci, Chunchon, South Korea.
[Ryu, Jong Hoon; Bae, Ho Jung] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul, South Korea.
[Ryu, Jong Hoon] Kyung Hee Univ, Coll Pharm, Dept Oriental Pharmaceut Sci, Seoul, South Korea.
[Liu, Xiang-Qian] Hunan Univ Chinese Med, Sch Pharm, Changsha, Peoples R China.
[Choi, Ji Woong] Gachon Univ, Coll Pharm, Lab Neuropharmacol, Incheon, South Korea.
通讯机构:
[Park, Se Jin; Ryu, Jong Hoon] K
Kangwon Natl Univ, Sch Nat Resources & Environm Sci, Chunchon, South Korea.
Kyung Hee Univ, Coll Pharm, Dept Oriental Pharmaceut Sci, Seoul, South Korea.
语种:
英文
关键词:
Dracocephalum moldavica;Memory impairment;Alzheimer's disease;Scopolamine;Extracellular signal regulated kinase;cAMP response element-binding protein
期刊:
Journal of Ethnopharmacology
ISSN:
0378-8741
年:
2020
卷:
253
页码:
112651-
基金类别:
National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF2017R1C1B5017445, NRF-2017R1A5A2014768]; Kangwon National University
机构署名:
本校为其他机构
院系归属:
药学院
摘要:
Ethnopharmacological relevance: Dracocephalum moldavica (Moldavian balm) has been traditionally used for the treatment of intellectual disabilities, migraines and cardiovascular problems in East Asia. Recent scientific studies have demonstrated the usefulness of this plant to treat neurodegenerative disorders, including Alzheimer's disease. Aim of the study: This study aimed to investigate the effects of the ethanolic extract of D. moldavica leaves (EEDM) on scopolamine-induced cognitive impairment in mice and the underlying mechanisms of actio...

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