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Dracocephalum moldavica attenuates scopolamine-induced cognitive impairment through activation of hippocampal ERK-CREB signaling in mice

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成果类型:
期刊论文
作者:
Deepa, Ponnuvel;Bae, Ho Jung;Park, Hyeon-Bae;Kim, So-Yeon;Choi, Ji Woong;...
通讯作者:
Park, SJ;Ryu, JH
作者机构:
[Kim, So-Yeon; Deepa, Ponnuvel; Park, SJ; Park, Se Jin; Park, Hyeon-Bae] Kangwon Natl Univ, Sch Nat Resources & Environm Sci, Chunchon, South Korea.
[Ryu, Jong Hoon; Bae, Ho Jung] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul, South Korea.
[Ryu, Jong Hoon; Ryu, JH] Kyung Hee Univ, Coll Pharm, Dept Oriental Pharmaceut Sci, Seoul, South Korea.
[Liu, Xiang-Qian] Hunan Univ Chinese Med, Sch Pharm, Changsha, Peoples R China.
[Choi, Ji Woong] Gachon Univ, Coll Pharm, Lab Neuropharmacol, Incheon, South Korea.
通讯机构:
[Ryu, JH ; Park, SJ ] K
Kangwon Natl Univ, Sch Nat Resources & Environm Sci, Chunchon, South Korea.
Kyung Hee Univ, Coll Pharm, Dept Oriental Pharmaceut Sci, Seoul, South Korea.
语种:
英文
关键词:
acetylcholinesterase;cyclic AMP responsive element binding protein;donepezil;Dracocephalum moldavica extract;mitogen activated protein kinase;neuroprotective agent;nootropic agent;oleanolic acid;plant extract;rosmarinic acid;unclassified drug;acetylcholinesterase;cyclic AMP responsive element binding protein;mitogen activated protein kinase;neuroprotective agent;plant extract;scopolamine;animal behavior;animal cell;animal experiment;animal model;animal tissue;Article;brain cortex;controlled study;Dracocephalum moldavica;drug mechanism;enzyme activation;enzyme activity;enzyme phosphorylation;footshock;hippocampal tissue;hippocampus;latent period;locomotion;male;MAPK signaling;memory disorder;Morris water maze test;motor coordination;mouse;neuroprotection;nonhuman;passive avoidance;plant leaf;protein expression;scopolamine-induced cognitive defect;step-through passive avoidance test;animal;avoidance behavior;cognitive defect;drug effect;hippocampus;Institute for Cancer Research mouse;Lamiaceae;maze test;metabolism;phosphorylation;signal transduction;Acetylcholinesterase;Animals;Avoidance Learning;Behavior, Animal;Cognitive Dysfunction;Cyclic AMP Response Element-Binding Protein;Extracellular Signal-Regulated MAP Kinases;Hippocampus;Lamiaceae;Male;Maze Learning;Mice, Inbred ICR;Neuroprotective Agents;Phosphorylation;Plant Extracts;Plant Leaves;Scopolamine;Signal Transduction
期刊:
Journal of Ethnopharmacology
ISSN:
0378-8741
年:
2020
卷:
253
页码:
112651
基金类别:
This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT ( NRF-2017R1C1B5017445 ; NRF-2017R1A5A2014768 ) and 2018 Research Grant from Kangwon National University . This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT (NRF-2017R1C1B5017445; NRF-2017R1A5A2014768) and 2018 Research Grant from Kangwon National University.
机构署名:
本校为其他机构
院系归属:
药学院
摘要:
Ethnopharmacological relevance: Dracocephalum moldavica (Moldavian balm) has been traditionally used for the treatment of intellectual disabilities, migraines and cardiovascular problems in East Asia. Recent scientific studies have demonstrated the usefulness of this plant to treat neurodegenerative disorders, including Alzheimer's disease. Aim of the study: This study aimed to investigate the effects of the ethanolic extract of D. moldavica leaves (EEDM) on scopolamine-induced cognitive impairment in mice and the underlying mechanisms of actio...

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