LncRNA SCIRT is Downregulated in Acute Myeloid Leukemia and Sponges miR-21 in Cytoplasm to Increase Chemosensitivity to Doxorubicin

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Haixia;Tian, Xuefei;Nie, Tian;Huang, Mao;Xiao, Zhenghui

通讯作者：

Xiao, Z.

作者机构：

[Li, Haixia] Hunan Childrens Hosp, Dept Tradit Chinese Med, Changsha 410007, Hunan, Peoples R China.

[Tian, Xuefei] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, 300 Shi Rd, Changsha 410208, Hunan, Peoples R China.

[Nie, Tian] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Hematol, 95 Shaoshan Zhong Lu, Changsha 410007, Hunan, Peoples R China.

[Huang, Mao] Hebei Prov Hosp Tradit Chinese Med, Dept Rehabil, 389 Zhongshan Dong Lu, Shijiazhuang 050000, Hebei, Peoples R China.

[Xiao, Zhenghui] Hunan Childrens Hosp, Emergency Ctr, 86 Ziyuan Rd, Changsha 410007, Hunan, Peoples R China.

通讯机构：

Emergency Center of Hunan Children’s Hospital, No. 86 Ziyuan Road, Yuhua District, Hunan Province, Changsha City, China

语种：

英文

关键词：

SCIRT;acute myeloid leukemia;miR-21;doxorubicin;apoptosis

期刊：

Critical Reviews in Eukaryotic Gene Expression

ISSN：

1045-4403

年：

2022

卷：

期：

页码：

61-69

DOI：

10.1615/CritRevEukaryotGeneExpr.2021039618

基金类别：

Hunan Provincial Natural Science Foundation of China [2020JJ4066]; National Natural Sci-ence Foundation of China [82074450]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

中西医结合学院

摘要：

Background: This study aimed to explore the role of SCIRT in acute myeloid leukemia (AML) and its interaction with miR-21. Methods: This study included 66 AML patients who were diagnosed with AML and received doxorubicin (Dox) treatment. Bone marrow was isolated from all patients before and after treatment to prepare BM mononuclear cells (BMMNCs). BMMNCs from another 60 healthy controls were also collected. The expression of SCIRT and miR-21 were analyzed with RT-qPCR. Subcellular location of SCIRT was analyzed with cellular fractionation assay...

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LncRNA SCIRT is Downregulated in Acute Myeloid Leukemia and Sponges miR-21 in Cytoplasm to Increase Chemosensitivity to Doxorubicin

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