Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway

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成果类型：

期刊论文

作者：

Mei, Zhi-Gang;Huang, Ya-Guang;Feng, Zhi-Tao*;Luo, Ya-Nan;Yang, Song-Bai;...

通讯作者：

Feng, Zhi-Tao;Luo, YN

作者机构：

[Deng, Yi-Hui; Mei, Zhi-Gang] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha, Hunan, Peoples R China.

[Fu, Xian-Yun; Du, Li-Peng; Luo, YN; Feng, Zhi-Tao; Liu, Xiao-Lu; Luo, Ya-Nan; Jiang, Kang; Feng, ZT; Mei, Zhi-Gang] China Three Gorges Univ, Third Grade Pharmacol Lab Chinese Med Approved St, Med Coll, Yichang, Hubei, Peoples R China.

[Huang, Ya-Guang] China Three Gorges Univ, Affiliated Renhe Hosp, Yichang, Hubei, Peoples R China.

[Yang, Song-Bai] China Three Gorges Univ, Yichang Hosp Tradit Chinese Med, Clin Med Coll Tradit Chinese Med, Yichang, Hubei, Peoples R China.

[Zhou, Hua-Jun] China Three Gorges Univ, Inst Neurol, Coll Clin Med Sci 1, Yichang, Hubei, Peoples R China.

通讯机构：

[Luo, YN ; Feng, ZT] C

China Three Gorges Univ, Third Grade Pharmacol Lab Chinese Med Approved St, Med Coll, Yichang, Hubei, Peoples R China.

语种：

英文

关键词：

FOXO1;SIRT1;autophagy;cerebral ischemia/reperfusion;electroacupuncture

期刊：

AGING-US

ISSN：

1945-4589

年：

2020

卷：

期：

页码：

13187-13205

DOI：

10.18632/aging.103420

基金类别：

This work was supported by the National Natural Science Foundation of China (No. 81202625), the Science and Technology Project of Yichang, Hubei (NO. A19-301-42) and Research Fund for Excellent Dissertation of China Three Gorges University (NO. 2019SSPY112).

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摘要：

Cerebral ischemia/reperfusion (CIR) injury occurs when blood flow is restored in the brain, causing secondary damage to the ischemic tissues. Previous studies have shown that electroacupuncture (EA) treatment contributes to brain protection against CIR injury through modulating autophagy. Studies indicated that SIRT1-FOXO1 plays a crucial role in regulating autophagy. Here we investigated the mechanisms underlying the neuroprotective effect of EA and its role in modulating autophagy via the SIRT1-FOXO1 signaling pathway in rats with CIR injury. EA pretreatment at "Baihui", "Quchi" and "Zusanli...

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Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway

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