Quantitative Proteomics Reveals the Dynamic Pathophysiology Across Different Stages in a Rat Model of Severe Traumatic Brain Injury

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成果类型：

期刊论文

作者：

Luo, Weikang;Yang, Zhaoyu;Zhang, Wei;Zhou, Dan;Guo, Xiaohang;...

通讯作者：

Wang, Yang

作者机构：

[Wang, Yang; Luo, Weikang; Yang, Zhaoyu] Cent South Univ, Xiangya Hosp, Inst Integrat Med, Dept Integrated Chinese & Western Med, Changsha, Peoples R China.

[Wang, Yang; Luo, Weikang; Yang, Zhaoyu] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.

[Zhang, Wei] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha, Peoples R China.

[Zhou, Dan] Hunan Univ Chinese Med, Period Off, Changsha, Peoples R China.

[Guo, Xiaohang] Hunan Univ Chinese Med, Med Sch, Changsha, Peoples R China.

通讯机构：

[Wang, Yang] C

Cent South Univ, Xiangya Hosp, Inst Integrat Med, Dept Integrated Chinese & Western Med, Changsha, Peoples R China.

Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.

语种：

英文

关键词：

quantitative proteomic;Severe traumatic brain injury;characteristic mechanisms;acute phase;Subacute phase;tandem mass tag-based

期刊：

Frontiers in Molecular Neuroscience

ISSN：

1662-5099

年：

2022

卷：

页码：

785938

DOI：

10.3389/fnmol.2021.785938

基金类别：

This work was supported by the National Natural Science Foundation of China (Grant Numbers: 81973665 and 81673719); the Science and Technology Innovation Program of Hunan Province (2021RC3030); the Hunan Provincial Natural Science Foundation of China (Grant Number: 2019JJ30042); the Innovation-Driven Project of Central South University (Grant Number: 2020CX047); and the project of inheritance studio for famous national experts of Traditional Chinese Medicine (Grant Number: [2018]134).

机构署名：

本校为其他机构

院系归属：

医学院

中西医结合学院

摘要：

Background: Severe traumatic brain injury (TBI) has become a global health problem and causes a vast worldwide societal burden. However, distinct mechanisms between acute and subacute stages have not been systemically revealed. The present study aimed to identify differentially expressed proteins in severe TBI from the acute to subacute phase. Methods: Sixty Sprague Dawley (SD) rats were randomly divided into sham surgery and model groups. The severe TBI models were induced by the controlled cortical impact (CCI) method. We evaluated the neurol...

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Quantitative Proteomics Reveals the Dynamic Pathophysiology Across Different Stages in a Rat Model of Severe Traumatic Brain Injury

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