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Hybrid-cell membrane-coated nanocomplex-loaded chikusetsusaponin IVa methyl ester for a combinational therapy against breast cancer assisted by Ce6

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成果类型:
期刊论文
作者:
Xie, Qian;Liu, Yang;Long, Ying;Wang, Zhou;Jiang, Sai;...
通讯作者:
Liu, Bin;Wang, W;Liu, B
作者机构:
[Ahmed, Rida; Wang, Wei; Jiang, Sai; Liu, Yang; Liu, Bin; Li, Bin; Xie, Qian; Daniyal, Muhammad; Liu, B] Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Peoples R China.
[Liu, B; Wang, Zhou; Long, Ying; Liu, Bin] Hunan Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China.
通讯机构:
[Liu, B ; Wang, W ; Liu, B] H
Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Peoples R China.
Hunan Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China.
语种:
英文
期刊:
BIOMATERIALS SCIENCE
ISSN:
2047-4830
年:
2021
卷:
9
期:
8
页码:
2991-3004
基金类别:
This work was financially supported by National Natural Science Foundation of China (81703819, 81874369, 81803708), Natural Science Foundation of Hunan Province (2020JJ4463, 2020JJ4064 and 2020JJ4005); Research Foundation of Education Bureau of Hunan Province (20A367).
机构署名:
本校为第一且通讯机构
院系归属:
药学院
摘要:
Breast cancer is the most common cancer in women and occurs mostly with poor outcomes. Our objective was to endow synthetic lethality to the phytoconstituent chikusetsusaponin IVa methyl ester (CSME, S), a special phytoconstituent from traditional Chinese medicine (TCM), Panax japonicus, with the photodynamic agent chlorin e6 (Ce6, C) and enhance the therapeutic efficacy against breast cancer using cell membrane-coated liposome nanoparticles (liposome, L). The delivery system based on liposomes was camouflaged by a hybrid cell membrane (RBC mem...

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