Axonopathy Likely Initiates Neuropathological Processes Via a Mechanism of Axonal Leakage in Alzheimer\'s Mouse Models - 成果

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Axonopathy Likely Initiates Neuropathological Processes Via a Mechanism of Axonal Leakage in Alzheimer's Mouse Models

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Gao, Ge;He, Jing;Luo, Yi;Sun, Yan;Zhou, Yanping;...

通讯作者：

Xing, Ying;Dai, Jiapei

作者机构：

[Xing, Ying; Gao, Ge; Zhang, Junxia] Zhengzhou Univ, Sch Basic Med Sci, 100 Kexue Rd, Zhengzhou 450001, Henan, Peoples R China.

[Zhou, Yanping; Luo, Yi; He, Jing; Sun, Yan; Dai, Jiapei] South Cent Univ Nationalities, Wuhan Inst Neurosci & Neuroengn, Minzu Dadao 708, Wuhan 430074, Hubei, Peoples R China.

[Sun, Yan; Dai, Jiapei] South Cent Univ Nationalities, Coll Life Sci, Wuhan, Hubei, Peoples R China.

[He, Jing] Hunan Univ Chinese Med, Clin Lab, Affiliated Hosp 2, Changsha, Hunan, Peoples R China.

[Luo, Yi] Wuhan Univ, Zhongnan Hosp, Clin Lab, Wuhan, Hubei, Peoples R China.

通讯机构：

[Xing, Ying] Z

[Dai, Jiapei] S

Zhengzhou Univ, Sch Basic Med Sci, 100 Kexue Rd, Zhengzhou 450001, Henan, Peoples R China.

South Cent Univ Nationalities, Wuhan Inst Neurosci & Neuroengn, Minzu Dadao 708, Wuhan 430074, Hubei, Peoples R China.

语种：

英文

关键词：

Axonopathy;Axonal leakage;Senile plaques;Neurofibrillary tangles;Alzheimer's disease.

期刊：

Current Molecular Medicine

ISSN：

1566-5240

年：

2019

卷：

期：

页码：

183-195

DOI：

10.2174/1566524019666190405174908

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31640034]; South-Central University for Nationalities [XTZ15014, CZP 18008]

机构署名：

本校为其他机构

院系归属：

第二中医临床医学院

摘要：

Background: The formation of hyperphosphorylated tau and the production of β-amyloid are thought to be critical steps contributing to the pathological mechanisms in Alzheimer’s disease (AD). However, there has been a long-lasting debate over their importance in the onset of AD. Recent studies have demonstrated that axonopathy is considered as an early neuropathological change of AD. However, the exact relationship between the development of axonopathy and the classic neuropathological changes such as senile plaques (SPs) and neurofibrillary t...

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Axonopathy Likely Initiates Neuropathological Processes Via a Mechanism of Axonal Leakage in Alzheimer's Mouse Models

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