期刊论文

中文

中国中药杂志

1001-5302

2015

40

20

4058-4062

10.4268/cjcmm20152030

国家重点基础研究发展计划（973）项目（2012CB723503） 湖南省教育厅科研项目（13C672） 湖南省中医药科研计划项目（2014135） 湖南省十二五中药学重点学科项目

本校为第一机构

评价补阳还五汤及其精简方(脑健片)对脑缺血体内模型大鼠海马组织周期蛋白CDK4/Cyclin D1的调控。将SD大鼠随机分为假手术组、模型组、补阳还五汤干预组(灌胃3.15 g?kg~(-1))及补阳精简方干预组(灌胃2.41 g?kg~(-1)),每组按给药后1,3,7,14,28 d再各分5组。采用免疫组化法和实时荧光定量PCR法考察不同时间点各组大鼠海马组织中CDK4/Cyclin D1的表达。结果发现脑缺血模型大鼠海马组织中,CDK4/Cyclin D1的表达上调,与假手术组比P

To evaluate the regulating effect of Buyang Huanwu decoction and its simple prescription (Naojian tablet) on CDK4/Cyclin D1 expression in hippocampus tissues of rats with cerebral ischemia, SD rats were divided into the sham-operation group, the model group, the Buyang Huanwu decoction group (ig, 3.15 g . kg(-)(1)) and the simple prescription group (ig, 2.41 g . kg(-)(1)). Each group was further divided into five subgroups based on time points after the administration, i. e. 1 d, 3 d, 7 d, 14 d and 28 d, respectively. CDK4/Cyclin D1 expressions of the group at different time points were examin...