Investigation into the Preparation of Paclitaxel Nanoparticles via Supercritical CO2 Fluid Dynamic Solvent Method, Structural Characterization, and In Vivo Distribution Kinetics in Rats

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

GuangYu Chen;Qun He;PeiPei Zhang;Liang Li;MengZhou Xie;...

通讯作者：

HaoYu Qu

作者机构：

Engineering Technology Research Center for Medicinal and Functional Food, Hunan University of Chinese Medicine, ChangSha, 410208, China

Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine, ChangSha, 410208, China

Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, ChangSha, 410208, China

School of Informatic, Hunan University of Chinese Medicine

[GuangYu Chen; Qun He; PeiPei Zhang; Liang Li; MengZhou Xie] Engineering Technology Research Center for Medicinal and Functional Food, Hunan University of Chinese Medicine, ChangSha, 410208, China<&wdkj&>Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine, ChangSha, 410208, China<&wdkj&>Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, ChangSha, 410208, China

通讯机构：

[HaoYu Qu] E

Engineering Technology Research Center for Medicinal and Functional Food, Hunan University of Chinese Medicine, ChangSha, 410208, China<&wdkj&>Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine, ChangSha, 410208, China<&wdkj&>Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, ChangSha, 410208, China<&wdkj&>School of Informatic, Hunan University of Chinese Medicine

语种：

英文

期刊：

Surfaces and Interfaces

ISSN：

2468-0230

年：

2025

页码：

106642

DOI：

10.1016/j.surfin.2025.106642

基金类别：

CRediT authorship contribution statement GuangYu Chen: Writing – review & editing, Writing – original draft, Visualization, Validation, Supervision, Software, Resources, Project administration, Methodology, Investigation, acquisition, Formal analysis, Data curation, Conceptualization. Qun He: Visualization, Validation, Supervision, Software, Resources, Project administration, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. PeiPei Zhang: Data curation. Liang Li: acquisition. MengZhou Xie:

机构署名：

本校为第一且通讯机构

院系归属：

中医诊断研究所

摘要：

Paclitaxel (PTX) is a lipophilic drug with potent anti-cancer activity. However, the conventional preparation method of paclitaxel nanoparticles (PTXNPS) typically requires the use of toxic organic solvents, which not only raises safety concerns for the formulation but also poses significant challenges to the large-scale commercial production of nano-drug formulations. This study developed a method for preparing PTXNPS using polyethylene glycol-polycaprolactone (PEG-PCL) as the nano-drug delivery excipient via the supercritical CO 2 fluid dynam...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Investigation into the Preparation of Paclitaxel Nanoparticles via Supercritical CO2 Fluid Dynamic Solvent Method, Structural Characterization, and In Vivo Distribution Kinetics in Rats

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问