期刊论文

Lowing-intraocular pressure and improving aqueous humor dynamic effects of qingguangan drug granules in spontaneous glaucoma mice

Peng, Q.

中文

中华实验眼科杂志

2095-0160

2017

35

12

1079-1084

10.3760/cma.j.issn.2095-0160.2017.12.006

(81403437):国家自然科学基金项目 (2015M570681):中国博士后基金面上项目 (2015JJ3097):湖南省自然科学基金项目 (14B137):湖南省教育厅科研基金优秀青年项目 :国家中医药管理局中医眼科学重点学科建设项目 :湖南省中医五官科学重点学科建设项目 (81403437):National Natural Science Foundation of China (2015M570681):Chinese Postdoctoral Foundation (2015JJ3097):Hunan Provincial Natural Science Foundation (14B137):Fund for Outstanding Youth of Hunan Educational Department :National Key Laboratory of Taditional Chinese Medicine Key Foundation :Key Laboratory of Hunan Traditional Chinese Medicine

本校为第一且通讯机构

背景研究表明青光眼的眼压增高与转化生长因子-β(TGF-β)促进小梁网细胞外基质的堆积以及黏附分子CD44导致房水排出阻力增加有关。传统中药青光安颗粒剂是中医临床上常用的降眼压药物,其是否通过小梁网通路发挥作用尚不清楚。目的研究青光安颗粒剂对自发性青光眼模型DBA/2J小鼠房水动力学的影响及其作用机制。方法选取10只眼压正常的3月龄雌性DBA/2J小鼠作为对照组,采用计算机随机数字分配法将20只9月龄自发性眼压升高的DBA/2J小鼠随机分为高眼压组和青光安组,青光安组小鼠采用2.5 g/kg复方青光安颗粒剂灌胃,每天2次,连续15 d,对照组和高眼压组小鼠以相同剂量生理盐水灌胃。采用经前房注入/抽吸...

Background: Researches showed that the increase of intraocular pressure (IOP) in glaucomatous eye is associated with the increasing resistance to aqueous humor outflow effects of transforming growth factor-β (TGF-β) and CD44.Qingguangan is a traditional Chinese medicine and used to treat glaucoma. However, its mechanism of lowing-IOP effect is not elucidated. Objective: This study was to investigate the lowing-IOP effect and mechanism of qingguangan granule in DBA/2J mouse, a spontaneous glaucoma model mice. Methods: Ten 3 month-old female DB...