Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by Astragaloside IV activation of the SIRT1/PGC1α /Nrf1 signaling pathway.

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成果类型：

期刊论文

作者：

Li, Liu;Zou, Junju;Zhou, Min;Li, Hong;Zhou, Tongyi;...

作者机构：

[Zhou, Tongyi; Yang, Shiyao; Liu, Xiu; Li, Hong; Zou, Junju; Li, Liu; Zhou, Min; Yu, Rong; Xiang, Qin; Huang, Qiuqing] School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China

[Zhou, Tongyi; Yang, Shiyao; Liu, Xiu; Li, Hong; Zou, Junju; Li, Liu; Zhou, Min; Xiang, Qin; Huang, Qiuqing] Hunan Key Laboratory of Traditional Chinese Medicine Prescription and Syndromes Translational Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China

[Yu, Rong] Hunan Key Laboratory of Traditional Chinese Medicine Prescription and Syndromes Translational Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China. Electronic address: yurong8072@qq.com

语种：

英文

关键词：

Astragaloside IV;Diabetic nephropathy;Mitochondrial dysfunction;Oxidative stress;Phenyl sulfate;Reactive oxygen species

期刊：

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

年：

2024

卷：

177

页码：

117008

DOI：

10.1016/j.biopha.2024.117008

机构署名：

本校为第一机构

摘要：

Astragaloside IV (AS-IV) exhibits diverse biological activities. Despite this, the detailed molecular mechanisms by which AS-IV ameliorates diabetic nephropathy (DN) and shields podocytes from oxidative stress (OS) and mitochondrial dysfunction remain poorly understood. In this study, we used biochemical assays, histopathological analysis, Doppler ultrasound, transmission electron microscopy，flow cytometry, fluorescence staining, and Western blotting and other methods. AS-IV was administered to db/db mice for in vivo experimentation. Our findi...

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Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by Astragaloside IV activation of the SIRT1/PGC1α /Nrf1 signaling pathway.

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