期刊论文

Qin, Li

英文

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

1388-1981

2020

1865

2

158547

10.1016/j.bbalip.2019.158547

This work was supported by grants from the National Natural Science Foundation of China (No. 81270359, No. 81774130, No. 81973668 and No. 81670268); The National Science Fund of Hunan Province for Distinguished Young Scholars (No. 2018JJ1018); and Hunan Provincial Innovation Foundation for Postgraduate (No. CX20190573). All authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. CjZ designed the study and wrote the manuscript and analyzed the data. ZN and ZL carried out experiments and analyzed the data. JL performed in vivo experiments. XyZ and ZwT provided clinical samples. ZS, ZyH and DfL revised themanuscrip. LQ designed and directed the project. All authors read and approved the final manuscript. The authors declare that they have no competing interests.

本校为第一且通讯机构

Atherosclerosis (AS) is characterized by lipids metabolism disorder and inflammatory response. Accumulating evidence has demonstrated that Wingless type 5a (Wnt5a) is implicated in cardiovascular diseases through non-canonical Wnt cascades. However, its precise role during the pathogenesis of AS is still unclear. Therefore, the present study aims to investigate the role and the underlying mechanism of Wnt5a/receptor tyrosine kinase-like orphan receptor 2 (Ror2) pathways in the promotion of AS process through affecting lipid accumulation and inflammation. In atherosclerotic clinical samples, Wn...