期刊论文

中文

河北中医

1002-2619

2019

41

10

1532-1535,1539,封3

10.3969/j.issn.1002-2619.2019.10.020

湖南省中医药科研计划项目(编号:201211) 湖南中医药大学中西医结合一流学科开放基金项目(编号:2018ZXYJH33) 2017年校级大学生研究性学习和创新性实验计划课题(编号:14)。

本校为第一机构

目的 观察积雪草苷对兔耳创伤修复不同时期及转化生长因子β1(TGF-β1)、Smad3免疫组织化学表达的影响.方法 将24只新西兰白兔按照随机数字表法分为生理盐水1组、生理盐水2组、积雪草苷1组、积雪草苷2组4组,每组6只.积雪草苷干粉制备成1 000 mg/mL的注射液,现备现用.制作兔耳直径1 cm全层皮肤缺损模型,造模后5 d(创伤修复增殖期),生理盐水1组、积雪草苷1组每日8:00、20:00于兔耳创面处分别注射0.9％氯化钠注射液、积雪草苷液,每次0.2 mL,连用15 d.造模后30 d(创伤修复塑形期),生理盐水2组、积雪草苷2组每日8:00、20:00于兔耳创面处分别注射0.9％氯化钠注射液、积雪草苷液,每次0.2 mL,连用15 d.生...

Objective To observe the effect of asiaticoside on the expression of TGF-β1 and Smad3 in rabbit ears at different stages of trauma repair. Methods 24 New Zealand white rabbits were randomly divided into 4 groups: normal saline group 1, normal saline group 2, asiaticoside group 1 and asiaticoside group 2, with 6 rabbits in each group. The dry powder of asiaticoside was prepared into 1 000 mg/mL injection, which is now in use. A full-thickness skin defect model with a diameter of 1 cm in rabbit ear was maded. After the establishment of the model...