期刊论文

Influence on Aortic Atherosclerotic Plaques of Experimental Hyperlipidemia Combined with Atherosclerosis in Rabbit Model by Sini Decoction

中文

中华中医药学刊

1673-7717

2012

30

12

2661-2663+2838

10.13193/j.archtcm.2012.12.71.lvy.040

湖南省教育厅资助项目（06C629） 湖南省科技厅资助项目（2012SK3143）

本校为第一机构

目的:观察四逆汤对实验兔HLP合并AS模型主动脉粥样斑块影响.方法:通过高脂饲料喂养及耳缘静脉注射牛血清蛋白、皮下注射卵清白蛋白,造成兔HLP合并AS模型,分别给予西药(阿托伐他汀)、四逆汤(高、中、低剂量)的治疗方法.运用数码显微镜观察兔主动脉粥样斑块结构的变化.结果:(1)在主动脉粥样硬化斑块厚度方面,四逆汤各剂量组指标值与模型组相比,具有使主动脉粥样硬化斑块厚度数值减小的作用,差异具有统计学意义(P ＜0.05或P＜0.01).(2)在主动脉粥样硬化斑块面积方面,四逆汤低剂量组此方面数值小于模型组,但差异无统计学意义(P＞0.05)；四逆汤中、高剂量组此方面数值小于模型组,差异具有统计学意义(...

Objective：To observe the influence on aortic atherosclerotic plaques of experimental hyperlipidemia com bined with atherosclerosis in rabbit model by Sini Decoction. Methods：While fed with high fat food everyday and injected with BSA, egg - white protein, HLP combined AS rabbits were treated with different ways of Atorvastatin and three doses of Sini Decoction（high,middle and low doses）. Digital microscopic observation of rabbit aortic endothelial microstructure changes was made. Results ： （ 1 ） On the area of aortic atherosclerotic plaq...