* Supported by Young-middle Aged Science and Technological Fund of Hunan Province (No. 00JZY2145) 1. Department of Physiology, 2. Department of Science and Technology, Hunan University of Traditional Chinese Medicine, Changsha (410007) Correspondence to: GE Jin-wen, Tel: 0731--5381067; E-mail: cmgjw@t om. com Forty-eight SD rats were randomly divided into the model group with 21 rats in which sodium laurate was injected into the left internal carotid artery, the sham operation group with 21 rats in which sodium laurate was substituted with 0.9% sodium chloride solution, and the control group with 6 rats without any treatment. At 6, 12, and 24 h after operation, 4 rats were respectively executed for index observation in model and sham operation group as well as 4 rats in the control group, such as brain tissue triphenyltetrazolium chloride (TTC) dyeing, neurological deficit, plasma tissue-type plasminogen activator (tPA) activity, plasminogen activator inhibitor (PAl) activity, thromboxane Bz (TXBz) content, 6-keto-prostaglandin (6-keto-PGF1,) content, with 3 rats for histopathological analysis. At the same time, 2 rats in the control group were kept for histopathological analysis.
