Objective: To solve the problem of that the major Chinese medicinal Seal's Genitals in Huolizhuang Capsules was difficult to comminute. Methods: The influence factors in the processing of this Chinese medicinal on its comminution effectiveness were studied with the percentage of comminution as an examination marker, and the optimum process conditions were selected by the othogonal test. Results: The test results showed that the comminution effectiveness of processed Seal's Genitals was the best and the percentage of comminution was the highest ...