期刊论文

Chemical constituents from the biological transformation of Hericium erinaceus and Artemisia annua

中文

中成药

1001-1528

2019

41

8

1875-1879

10.3969/j.issn.1001-1528.2019.08.025

中药学湖南省重点学科科技项目(zy201501) 湖南省研究生科研创新项目(CX2015B323) 湖南中医药大学研究生一方科研创新项目(YF201703) 湖南新汇制药股份有限公司资助(50010079).

本校为第一机构

目的研究猴头菌Hericium erinaceus( Bull.) Pers.-青蒿Artemisia annua L.生物转化物的化学成分。方法猴头菌-青蒿生物转化物75%乙醇提取物采用硅胶、Sephadex LH-20凝胶柱、重结晶进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到10个化合物,分别鉴定为5α-豆甾-3-酮( 1) 、( 22E,24R)-啤酒甾醇( 2 ) 、3α-羟基脱氧青蒿素( 3 ) 、异莨菪亭( 4 ) 、nodakenetin( 5 ) 、( + ) -lomatin( 6 ) 、( + ) -tert-Omethylbyakangelicin( 7) 、5,7,4'-三羟基-3',5'-二甲氧基黄酮( 8) 、蒿黄素( 9 ) 、quercetagetin-3,7,3',4'- tetramethyl ether( 10) 。结论化合物5~ 7为首...

AIM To study the chemical constituents from the biological transformation of Hericium erinaceus ( Bull.) Pers. and Artemisia annua L.. METHODS The 75% ethanol extract from H. erinaceus and A. annua biological transformation was isolated and purified by silica,Sephadex LH-20 and recrystallization, then the structures of obtained compounds were identified by physicochemical properties and spectral data. RESULTS Ten compounds were isolated and identified as 5α-stigmasta-3-one ( 1),cerevisterol ( 2),3α-hydroxydeoxyartemisinin ( 3),isoscopoletin (...