In silico analysis of the potential mechanism of a preventive Chinese medicine formula on coronavirus disease 2019

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wu, Huaying;Gong, Ke;Qin, You;Yuan, Zhiying;Xia, Shuaishuai;...

作者机构：

[Wu, Huaying; Li, Liang; Xie, Mengzhou; Xia, Shuaishuai] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Sci & Educ Pk, Changsha 410208, Peoples R China.

[Gong, Ke; Yang, Jingjing] Dongtang Community Hlth Serv Ctr Yuhua Dist, Changsha, Peoples R China.

[Qin, You] Hunan Acad Chinese Med, Inst Chinese Mat Medial, Changsha, Peoples R China.

[Yuan, Zhiying] Hunan Univ Chinese Med, Coll Pharm, Changsha, Peoples R China.

[Zhang, Shiying] Peoples Hosp Luohu Dist, Dept Tradit Chinese Med, Shenzhen, Peoples R China.

语种：

英文

关键词：

Coronavirus disease 2019;Network pharmacology;Single-cell RNA Sequencing;Chinese medicine preventive formula;Close contacts;Molecular docking

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2021

卷：

275

页码：

114098-

DOI：

10.1016/j.jep.2021.114098

基金类别：

Scientific Research Fund of Hunan Administration of TCM [KYGG06, KYGG07]; Hunan Provincial Clinical Medical Technology Innovation Guidance Program [2017SK50315]; Hunan Provincial Mental Behavior Disorder Clinical Medicine Research Center [2018SK7002]; Hunan Province Innovation Guidance Project [2018SK50705]; Hunan Provincial Science and Technology Major Special Project [2018SK1030]

机构署名：

本校为第一机构

院系归属：

中医学院

药学院

中医诊断研究所

摘要：

ETHNOPHARMACOLOGICAL RELEVANCE: With the spread of Coronavirus Disease (2019) (COVID-19), combination with traditional Chinese medicine (TCM) has been widely used as a prevention and therapy strategy in China. Xin guan No.1 (XG-1) prescription is a preventive formula recommended by the Hunan Provincial Administration of TCM to prevent the pandemic of COVID-19. AIM OF THE STUDY: To explore the potential preventive mechanisms of XG-1 against COVID-19 in the combination of network pharmacology approach, single-cell RNA expression profiling analysi...

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In silico analysis of the potential mechanism of a preventive Chinese medicine formula on coronavirus disease 2019

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