Mechanistic Advances in Hypoglycemic Effects of Natural Polysaccharides: Multi-Target Regulation of Glycometabolism and Gut Microbiota Crosstalk

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成果类型：

期刊论文

作者：

Zhou, Liquan;Li, Jiani;Ding, Chen;Zhou, Yimiao*;Xiao, Zuowei

通讯作者：

Zhou, Yimiao;Xiao, ZW;Zhou, YM

作者机构：

[Li, Jiani; Zhou, Yimiao; Xiao, ZW; Zhou, Liquan; Xiao, Zuowei; Zhou, YM; Ding, Chen] Hunan Univ Chinese Med, Homologous Innovat Lab Med & Food, Changsha 410208, Peoples R China.

[Li, Jiani; Zhou, Yimiao; Xiao, ZW; Zhou, Liquan; Xiao, Zuowei; Zhou, YM; Ding, Chen] Hunan Univ Chinese Med, Hunan Engn & Technol Res Ctr Hlth Prod & Life Sci, Changsha 410208, Peoples R China.

[Li, Jiani; Zhou, Yimiao; Xiao, ZW; Zhou, Liquan; Xiao, Zuowei; Zhou, YM; Ding, Chen] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

[Zhou, Yimiao; Zhou, YM] Hunan Univ Chinese Med, Xiangxing Coll, Xiangyin Campus, Yueyang 414615, Peoples R China.

通讯机构：

[Xiao, ZW ; Zhou, YM ; Zhou, YM] H

Hunan Univ Chinese Med, Homologous Innovat Lab Med & Food, Changsha 410208, Peoples R China.

Hunan Univ Chinese Med, Hunan Engn & Technol Res Ctr Hlth Prod & Life Sci, Changsha 410208, Peoples R China.

Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

Hunan Univ Chinese Med, Xiangxing Coll, Xiangyin Campus, Yueyang 414615, Peoples R China.

语种：

英文

关键词：

gut microbiota;hypoglycemia;mechanism of action;natural polysaccharides;signaling pathway

期刊：

Molecules

ISSN：

1420-3049

年：

2025

卷：

期：

DOI：

10.3390/molecules30091980

基金类别：

Hunan Natural Science Foundation [2024JJ8163]; Key Project of Hunan Provincial Administration of Traditional Chinese Medicine [201923, C2023005]; Annual Natural Drug Resources and Function Development Fund Project [2022ZYYGN06]

机构署名：

本校为第一且通讯机构

院系归属：

药学院

湘杏学院

摘要：

Natural polysaccharides (NPs), as a class of bioactive macromolecules with multitarget synergistic regulatory potential, exhibit significant advantages in diabetes intervention. This review systematically summarizes the core hypoglycemic mechanisms of NPs, covering structure-activity relationships, integration of the gut microbiota-metabolism-immunity axis, and regulation of key signaling pathways. Studies demonstrate that the molecular weight, branch complexity, and chemical modifications of NPs mediate their hypoglycemic activity by influenci...

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Mechanistic Advances in Hypoglycemic Effects of Natural Polysaccharides: Multi-Target Regulation of Glycometabolism and Gut Microbiota Crosstalk

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