Detoxification and activating blood circulation decoction reduces restenosis involving the TLR4/NF-κB pathway after balloon injury

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成果类型：

期刊论文

作者：

Zou, Guohui*;Zhu, Jinhua;Liu, Zhongyong;Wu, Lu;Xu, Ri;...

通讯作者：

Zou, Guohui;Deng, Changqing

作者机构：

[Chen, Hongtao; Zou, Guohui; Liu, Zhongyong; Xu, Ri; Deng, Peng] Jiangxi Univ Tradit Chinese Med, Affiliated Hosp, Nanchang 330006, Jiangxi, Peoples R China.

[Zhu, Jinhua] Jiangxi Univ Tradit Chinese Med, Nanchang 330004, Jiangxi, Peoples R China.

[Wu, Lu] Hunan Univ Tradit Chinese Med, Affiliated Tradit & Western Med Hosp 2, Liuyang 410300, Peoples R China.

[Deng, Changqing] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Zou, Guohui] J

[Deng, Changqing] H

Jiangxi Univ Tradit Chinese Med, Affiliated Hosp, Nanchang 330006, Jiangxi, Peoples R China.

Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

*Detoxification and activating blood circulation decoction;*Inflammatory reaction;*PCI operation;*Restenosis;*TLR4/NF-kappaB;*VSMCs proliferation

期刊：

Prostaglandins & Other Lipid Mediators

ISSN：

1098-8823

年：

2019

卷：

140

页码：

1-8

DOI：

10.1016/j.prostaglandins.2018.11.002

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81760811]; research foundation of Jiangxi University of Traditional Chinese Medicine [2013ZR009]

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

Restenosis is a major problem after percutaneous coronary intervention (PCI) treatment. Inflammation is one of the major core mechanisms involved in the occurrence of restenosis, and plays an important role in intimal hyperplasia. Detoxification and activating blood circulation decoction (DABCD) is a traditional Chinese medicine that is used in the treatment and prevention of atherosclerotic and inflammatory diseases. Our previous studies demonstrated that DABCD-mediated cardioprotection involves anti-inflammatory mechanisms and could be developed as a novel drug for the treatment of vascular ...

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Detoxification and activating blood circulation decoction reduces restenosis involving the TLR4/NF-κB pathway after balloon injury

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