期刊论文

Human papillomavirus infection in married women and its subtype distribution in Beijing

中文

中国艾滋病性病

1672-5662

2012

18

9

604-606

10.13419/j.cnki.aids.2012.09.023

本校为第一机构

目的探讨北京地区妇女宫颈人乳头瘤病毒（HPV）感染及其亚型分布情况。方法采用聚合酶链反应（PCR）体外扩增和脱氧核糖核酸（DNA）反向点杂交相结合的DNA芯片技术,对920例宫颈脱落细胞标本进行HPV基因分型检测。结果 920例标本共检出HPV感染508例,总感染率为55.22%。23种亚型共检出21种,高危亚型MM4及低危亚型44未检测出;感染率居前五位的基因亚型是HPV-16 238例（24.74%）,HPV-11 100例（10.4%）,HPV-6 95例（9.88%）,HPV-58 84例（8.73%）和HPV-33 75例（7.8%）。单一基因型感染285例,占总感染数的56.1%;多重感染223例,占总感染数的43.9%。

Objective To study the human papillomavirus（HPV） infection in married females and its subtype distribution.Methods PCR and gene chip technology were used to test 920 cervical cell samples,and 23 HPV genotypes were detected.Results Among 508 positive samples,21 subtypes of 23 known subtypes were detected.The low risk subtype HPV-44 and high risk subtype HPV-MM4 had not been detected.Altogether 508（55.22%）women were HPV positive among 920 patients.Of 508 HPV positive cases,238（24.74%） were HPV-16,100（10.4%） were HPV-11,95（9.88%） were HP...