期刊论文

Li, Li;Lu, Cheng;Tan, Y;Yi, JF

英文

Biomedicine & Pharmacotherapy

0753-3322

2020

128

110184

10.1016/j.biopha.2020.110184

This work was supported by the National Science and Technology Major Project [2018ZX10101001-005-003, 2018ZX10101001-005-004, 2017YFC1703701]; the Fundamental Research Funds for the Central Public Welfare Research Institutes [Z0606, Z0558, Z0653, Z0656]; the Beijing TCM Science and Technology Development Fund Project [JJ2018-102]; the Open Project of the State Key Laboratory of Innovative Natural Medicine and TCM Injections [QFSKL2018003]; the International Cooperative Project of China Academy of Chinese Medical Sciences [GH201909]; the Project of Innovative Drug Pilot Engineering Research Center of Shaanxi Province of China [QHDR201811].

本校为其他机构

Bacterial biofilms widely exist in nature and seriously threaten global public health. Biofilms always cause persistent infection and seriously aggravate the occurrence of antibiotic resistance, which makes the treatment of bacterial infection difficult. Current conventional therapies, such as antibiotics, bacteriophages and quorum sensing inhibitors, are widely used to combat biofilms. However, these therapies are inadequate for the safe and effective treatment of biofilms. Antibiotics often produce resistance in treated bacteria, and antibacterial peptides are easily decomposed by proteases,...