Well-being and biological cost of family members affected by substance use disorder of others

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成果类型：

期刊论文

作者：

Chen, Zhao-Rong;Zhang, Nian-Nian;Cao, Wen-Yu;Liu, Qian;Cui, Yan-Hui;...

通讯作者：

Li, Fang;Li, CQ

作者机构：

[Li, Chang-Qi; Li, CQ; Lu, Xiao-Yu; Li, Fang; Cui, Yan-Hui; Yao, Jia-Yu; Li, F; Chen, Zhao-Rong] Cent South Univ, Xiangya Sch Basic Med Sci, Dept Anat & Neurobiol, Changsha 410013, Hunan, Peoples R China.

[Chen, Zhao-Rong] Hunan Univ Chinese Med, Grad Sch, Changsha 410208, Hunan, Peoples R China.

[Zhang, Nian-Nian] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China.

[Cao, Wen-Yu] Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Liu, Qian] Lituo Drug Rehabil Inst Hunan Prov, Changsha 410000, Hunan, Peoples R China.

通讯机构：

[Li, CQ ; Li, F] C

Cent South Univ, Xiangya Sch Basic Med Sci, Dept Anat & Neurobiol, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

Substance use disorder;Affected family members;Mental health;Social avoidance;Quality of life;BDNF;Cortisol

期刊：

European Archives of Psychiatry and Clinical Neuroscience

ISSN：

0940-1334

年：

2025

页码：

1-13

DOI：

10.1007/s00406-025-02019-7

基金类别：

This work was supported by the National Natural Science Foundation of China (Grant No. 32371210) and the Natural Science Foundation of Hunan Province, China (Grant No. 2023JJ30724).

机构署名：

本校为其他机构

院系归属：

研究生院

摘要：

This cross-sectional study assessed the well-being of family members affected (AFMs) by substance use disorder (SUD) of other family members. Mental symptoms, social avoidance, and quality of life (QoL) were measured for 775 Chinese AFMs and 206 controls. Saliva from 65 AFMs and 31 controls was analyzed for cortisol, BDNF, proBDNF, and mRNA levels of BDNF and its receptors (TrkB, P75(NTR), Sortilin). AFMs had significantly higher SCL-90 scores (t = 3.45, p

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Well-being and biological cost of family members affected by substance use disorder of others

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