MiR-100 inhibits cell growth and proliferation by targeting HOXA1 in nasopharyngeal carcinoma

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成果类型：

期刊论文

作者：

He, Weifeng;Huang, Yun;Jiang, Cheng Chuan;Zhu, Yuan;Wang, Ling;...

通讯作者：

Zhou, Ting;Tang, SY

作者机构：

[He, Weifeng; Tang, Sanyuan; Zhou, Ting; Zhang, Weiwei; Jiang, Cheng Chuan] Brain Hosp Hunan Prov, Dept Oncol, Changsha 410007, Hunan, Peoples R China.

[Huang, Yun; Huang, Weiguo] Univ South China, Hengyang Med Coll, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.

[Zhu, Yuan] Peoples Hosp Changshou Chongqing, Chongqing 401220, Peoples R China.

[Wang, Ling] Yi Chang Cent Peoples Hosp, Yichang 443000, Hubei, Peoples R China.

[Zhou, Ting] Hunan Univ Tradit Chinese Med, Coll Pharm, Dept Clin Pharm, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Tang, SY ; Zhou, T] B

Brain Hosp Hunan Prov, Dept Oncol, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

homeobox protein Hox A1;microRNA 100;transcription factor;unclassified drug;animal experiment;animal model;animal tissue;Article;cancer growth;cell density;cell growth;cell proliferation;colony formation;controlled study;female;human;human cell;in vitro study;in vivo study;mouse;MTT assay;nasopharynx carcinoma;nonhuman;plasmid;protein analysis;protein expression;protein function;protein targeting;quantitative analysis;reverse transcription polymerase chain reaction;RNA isolation;tumor volume;tumor xenograft;Western blotting

期刊：

ONCOTARGETS AND THERAPY

ISSN：

1178-6930

年：

2020

卷：

页码：

593-602

DOI：

10.2147/OTT.S228783

基金类别：

This work was supported by grants from Health Commission of Hunan Province (20190339 and B20180849); Natural Science Foundation of Hunan Province (2018JJ6120 and 2019JJ40159); and The Foundation of Brain Hospital of Hunan Province (2018). The funders had no role in the study design, data collection, analysis, decision to publish or the preparation of the manuscript. Science Foundation of Hunan Province (2018JJ6120 and 2019JJ40159); and The Foundation of Brain Hospital of Hunan Province (2018). The funders had no role in the study design, data collection, analysis, decision to publish or the preparation of the manuscript. This work was supported by grants from Health Commission of Hunan Province (20190339 and B20180849); Natural

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Background: Increasing evidence indicates that the dysregulation of miRNAs plays a vital role in tumorigenesis and progression of nasopharyngeal carcinoma (NPC). Thus, it is necessary to further investigate the function and mechanism of miRNAs in NPC. Methods: miR-100 expression was analyzed using publicly available databases and then tested using quantitative RT-PCR in NPC tissues and cell lines. MTT and colony formation assays and xenograft tumor model were used to test the NPC cell growth and proliferation abilities while modulating miR-100 ...

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MiR-100 inhibits cell growth and proliferation by targeting HOXA1 in nasopharyngeal carcinoma

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