Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity

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成果类型：

期刊论文

作者：

Tang, Zhen;Cheng, Shaowu;Sun, Yanyan;Zhang, Yunqiao;Xiang, Xiying;...

通讯作者：

Hei, Mingyan

作者机构：

[Zhu, Xing; Sun, Yanyan; Ouyang, Zhicui; Tang, Zhen] Cent South Univ, Xiangya Hosp 3, Dept Pediat, Changsha 410013, Hunan, Peoples R China.

[Cheng, Shaowu] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China.

[Zhang, Yunqiao] Kunming Med Univ, Affiliated Hosp 6, Neuropsychol Ctr, Kunming 653100, Yunnan, Peoples R China.

[Wang, Bo; Hei, Mingyan; Xiang, Xiying] Capital Med Univ, Beijing Childrens Hosp, Neonatal Ctr, Nanlishi Rd 56, Beijing 100045, Peoples R China.

通讯机构：

[Hei, Mingyan] C

Capital Med Univ, Beijing Childrens Hosp, Neonatal Ctr, Nanlishi Rd 56, Beijing 100045, Peoples R China.

语种：

英文

关键词：

Hypoxia-ischemia(HI);Neuroprotection;Brain injuries;Hippocampus;Toll-like receptor 4;Rat model

期刊：

Experimental Neurology

ISSN：

0014-4886

年：

2019

卷：

321

期：

页码：

113039

DOI：

10.1016/j.expneurol.2019.113039

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671505]

机构署名：

本校为其他机构

摘要：

Neonatal hypoxic-ischemic brain damage (HIBD) survivors present with long-term neurological disorders affecting their quality of life, and there remains a lack of effective treatment. Toll-like receptor 4 (TLR4) is widely distributed in nerve cells and its inhibition has a neuroprotective effect against brain injury. The present study aimed to evaluate the long-term neuroprotective effects of early inhibition of TLR4 during HIBD. Seven-day-old rat pups were subjected to left carotid artery ligation followed by 2 h of hypoxia (8.0% O-2). A single dose of TAK-242 (0.5 mg/kg), a TLR4-specific ant...

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Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity

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