Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity

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成果类型：

期刊论文

作者：

Tang, Zhen;Cheng, Shaowu;Sun, Yanyan;Zhang, Yunqiao;Xiang, Xiying;...

通讯作者：

Hei, MY

作者机构：

[Zhu, Xing; Sun, Yanyan; Ouyang, Zhicui; Tang, Zhen] Cent South Univ, Xiangya Hosp 3, Dept Pediat, Changsha 410013, Hunan, Peoples R China.

[Cheng, Shaowu] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China.

[Zhang, Yunqiao] Kunming Med Univ, Affiliated Hosp 6, Neuropsychol Ctr, Kunming 653100, Yunnan, Peoples R China.

[Wang, Bo; Hei, Mingyan; Hei, MY; Xiang, Xiying] Capital Med Univ, Beijing Childrens Hosp, Neonatal Ctr, Nanlishi Rd 56, Beijing 100045, Peoples R China.

通讯机构：

[Hei, MY ] C

Capital Med Univ, Beijing Childrens Hosp, Neonatal Ctr, Nanlishi Rd 56, Beijing 100045, Peoples R China.

语种：

英文

关键词：

Hypoxia-ischemia(HI);Neuroprotection;Brain injuries;Hippocampus;Toll-like receptor 4;Rat model

期刊：

Experimental Neurology

ISSN：

0014-4886

年：

2019

卷：

321

期：

页码：

113039

DOI：

10.1016/j.expneurol.2019.113039

基金类别：

This work is supported by the National Natural Science Foundation of China (No. 81671505). We are grateful for the substantial support of the central laboratory staff at the Third Xiangya Hospital of Central South University.

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摘要：

Neonatal hypoxic-ischemic brain damage (HIBD) survivors present with long-term neurological disorders affecting their quality of life, and there remains a lack of effective treatment. Toll-like receptor 4 (TLR4) is widely distributed in nerve cells and its inhibition has a neuroprotective effect against brain injury. The present study aimed to evaluate the long-term neuroprotective effects of early inhibition of TLR4 during HIBD. Seven-day-old rat pups were subjected to left carotid artery ligation followed by 2 h of hypoxia (8.0% O-2). A single dose of TAK-242 (0.5 mg/kg), a TLR4-specific ant...

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Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity

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