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Application of TQSM polypharmacokinetics and its similarity approach to ascertain Q-marker by analyses of transitivity in vivo of five candidates in Buyanghuanwu injection

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成果类型:
期刊论文
作者:
Zhang Yu-Tian;Xiao Mei-Feng;Liao Qiong;Liu Wen-Long;Deng Kai-Wen;...
通讯作者:
He Fu-Yuan;Yang Yan-Tao
作者机构:
[He Fu-Yuan; Yang, YT; Yang Yan-Tao; Tang Yu; Xiao Mei-Feng; Liu Wen-Long; Zhang Yu-Tian; Liao Qiong; Zhou Yi-Qun] Hunan Univ Chinese Med, Dept Pharmaceut, Coll Pharm, Changsha 410208, Hunan, Peoples R China.
[Yang Yan-Tao; He Fu-Yuan; Xiao Mei-Feng; Liu Wen-Long; Zhang Yu-Tian; Zhou Yi-Qun] Hunan Key Lab Druggabil & Preparat Modificat Trad, Changsha 410208, Hunan, Peoples R China.
[Deng Kai-Wen] Hunan Univ Tradit Chinese Med, Affinitied Hosp 1, Dept Acupuncture, Changsha 410208, Hunan, Peoples R China.
[He Fu-Yuan; Xiao Mei-Feng; Liu Wen-Long; Deng Kai-Wen; Zhou Yi-Qun] Chinese Mat Med, Dept Supramol Mech & Math Phys Characterizat, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[He, FY; Yang, YT; Yang Yan-Tao] H
Hunan Univ Chinese Med, Dept Pharmaceut, Coll Pharm, Changsha 410208, Hunan, Peoples R China.
Hunan Key Lab Druggabil & Preparat Modificat Trad, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
Astragaloside;BYHWI;CMM;Polypharmacokinetics;Q-marker;TQSM similarity
期刊:
Phytomedicine
ISSN:
0944-7113
年:
2018
卷:
45
页码:
18-25
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81573691]; Hunan Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2016JJ4065]
机构署名:
本校为其他机构
院系归属:
药学院
摘要:
Background: It is well-known that the public still have been facing on a severe issue about the inconsistency of quality and therapeutic efficacy of traditional medicines. Recently, Professor Chang-Xiao Liu has created a new promising concept for identifying relevant quality-markers (Q-marker) from herbs, their formulas and manufacturing products. Therefore, building up a new approach is necessary for us to bridge over quality to efficacy of pharmaceutical products. Study design: In this paper, five candidate Q-markers, astragaloside IV, paeonflorin, amygdalin, tetra-methylpyrazine, ferulic ac...

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