Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways

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成果类型：

期刊论文

作者：

Wang, Lihuai;Wen, Jing;Sun, Yinhui;Yang, Xiao;Ma, Yi;...

通讯作者：

Tian, XF

作者机构：

[Wang, Lihuai] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

[Ma, Yi; Wen, Jing; Yang, Xiao] Hunan Univ Chinese Med, First Hosp 1, Dept Androl, Changsha 410007, Hunan, Peoples R China.

[Sun, Yinhui] Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.

[Tian, Xuefei; Tian, XF] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Tian, XF ] H

Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

NUPR1;lung cancer;angiogenesis;signaling pathways

期刊：

Open medicine (Warsaw, Poland)

ISSN：

2391-5463

年：

2023

卷：

期：

页码：

20230796

DOI：

10.1515/med-2023-0796

基金类别：

Not applicable.

机构署名：

本校为第一机构

院系归属：

医学院

中西医结合学院

摘要：

The stress response molecule nuclear protein‑1 (NUPR1) is essential for the growth of multiple types of human malignant tumor cells. However, the significance of NUPR1 in lung cancer is still not entirely elucidated. Therefore, this study is aimed to explore the function and underlying mechanisms of NUPR1 in lung cancer. NUPR1 mRNA and protein levels in lung cancer cell lines (A549 or H1299 cells) were silenced through siRNA transfection and western blot observed its successful infection efficiency. Then, using tube formation and wound healing...

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Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways

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