期刊论文

中文

中医杂志

1001-1668

2015

56

6

511-514

10.13288/j.11-2166/r.2015.06.017

国家自然科学基金（81273753） 湖南省自然科学基金（12JJ2048,12JJ9031）

本校为第一机构

目的探讨左归降糖益肾方治疗糖尿病肾病(DN)的效果及可能作用机制。方法40只MKR小鼠随机分为MKR鼠组、模型组、中药组和西药组,每组10只,同期另设10只C57小鼠为对照组。模型组、中药组、西药组均予高脂饮食联合右肾切除建立糖尿病肾病模型,术后8周中药组给予左归降糖益肾方溶液28g/(kg·d),西药组给予格列喹酮片7.9mg/(kg·d)和贝那普利片1.3mg/(kg·d),其余各组均以等量蒸馏水灌胃,每日1次,连续8周。检测各组小鼠空腹血糖、尿微量白蛋白(UmA1b)、肾小球足细胞凋亡水平及Bcl-2 mRNA、Bax mRNA和蛋白表达水平。结果模型组可见凋亡细胞明显增多,多数为肾小球内的足细胞,中药组及西药组足细胞凋亡情...

Objective To observe the effect of Zuogui Jiangtang Yishen Formula（ ZJYF） in treating diabetic nephropathy（ DN） and discuss the possible mechanism. Methods 40 muscle IGF-I receptor（ IGF-IR）-lysinearginine（ MKR） mice were randomly divided into MKR group,model group,TCM group,and western medicine group,with 10 in each,and another 10 C57 mice were set as control group. The model group,TCM group,and western medicine group were given high fat diet in combination with resection of the right kidney to establish the DN models. Eight weeks after...