Antihepatoma peptide, scolopentide, derived from the centipede scolopendra subspinipes mutilans

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu, Yu-Xing;Liu, Zhuo;Zhang, Zhen;Deng, Zhe;Huang, Zhen;...

通讯作者：

Tian, XF

作者机构：

[Tian, Xue-Fei; Zhang, Zhen; Tian, Sha; Feng, Ting; Huang, Zhen; Deng, Zhe; Hu, Yu-Xing] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

[Tian, Xue-Fei; Hu, Yu-Xing] Hunan Univ Chinese Med, Hunan Key Lab Translat Res Formulas & Zheng Tradit, Changsha 410208, Hunan, Peoples R China.

[Zhang, Zhen; Liu, Zhuo] Hunan Acad, Tradit Chinese Med Affiliated Hosp, Dept Sci Res, Changsha 410208, Hunan, Peoples R China.

[Deng, Zhe] Hunan Univ Chinese Med, Hunan Prov Univ Key Lab Oncol Tradit Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Zhou, Qing-Hong] Beijing Univ Chinese Med, Shenzhen Hosp, Dept Pediat, Shenzhen 518000, Guangdong, Peoples R China.

通讯机构：

[Tian, XF ] H

Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Scolopendra;Centipede;Antihepatom peptide;Hepatocellular carcinoma;Death receptor 4;Death receptor 5

期刊：

世界胃肠病学杂志：英文版

ISSN：

1007-9327

年：

2023

卷：

期：

页码：

1875-1898

DOI：

10.3748/wjg.v29.i12.1875

基金类别：

National Natural Science Foundation of China [U20A20408, 82074450]; Natural Science Foundation of Hunan Province [2020JJ4066, 2021JJ40405]; Key scientific research project of Hunan Education Department [21A0243]; Key project of academician workstation guidance project [21YSZQ007]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

中西医结合学院

药学院

摘要：

BACKGROUND Centipedes have been used to treat tumors for hundreds of years in China. However, current studies focus on antimicrobial and anticoagulation agents rather than tumors. The molecular identities of antihepatoma bioactive components in centipedes have not yet been extensively investigated. It is a challenge to isolate and characterize the effective components of centipedes due to limited peptide purification technologies for animal-derived medicines. AIM To purify, characterize, and synthesize the bioactive components with the strongest antihepatoma activity from centipedes and determ...

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Antihepatoma peptide, scolopentide, derived from the centipede scolopendra subspinipes mutilans

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