Metabolomics Analysis of Hippocampus and Cortex in a Rat Model of Traumatic Brain Injury in the Subacute Phase

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成果类型：

期刊论文

作者：

Zheng, Fei;Zhou, Yan-Tao;Li, Peng-Fei;Hu, En;Li, Teng;...

通讯作者：

Wang, Y;Zhang, W;Ding, CS

作者机构：

[Zhou, Yan-Tao; Zheng, Fei] Hunan Univ, Coll Elect & Informat Engn, Changsha, Peoples R China.

[Luo, Jie-Kun; Hu, En; Wang, Yang; Tang, Tao; Li, Teng; Li, Peng-Fei] Cent South Univ, Inst Integrated Tradit Chinese & Western Med, Xiangya Hosp, Lab Ethnopharmacol, Changsha, Peoples R China.

[Zhang, Wei] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha, Peoples R China.

[Ding, Chang-Song] Hunan Univ Chinese Med, Sch Informat, Changsha, Peoples R China.

通讯机构：

[Zhang, W ; Ding, CS ] H

[Wang, Y ] C

Cent South Univ, Inst Integrated Tradit Chinese & Western Med, Xiangya Hosp, Lab Ethnopharmacol, Changsha, Peoples R China.

Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha, Peoples R China.

Hunan Univ Chinese Med, Sch Informat, Changsha, Peoples R China.

语种：

英文

关键词：

Traumatic Brain Injury;Hippocampus and cortex;Metabolomics;LC-MS/MS;Subacute phase

期刊：

Frontiers in Neuroscience

ISSN：

1662-4548

年：

2020

卷：

页码：

532068

DOI：

10.3389/fnins.2020.00876

基金类别：

Funding. This work was supported by the National Natural Science Foundation of China (Nos. 81673719 and 61472126), the Hunan Provincial Natural Science Foundation of China (No. 2019JJ30042), the Outstanding Youth Fund of Hunan Natural Science (No. 2020JJ2024), and Natural Science Foundation of Hunan Province (No. 2018JJ2301).

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

Traumatic brain injury (TBI) is a complex and serious disease as its multifaceted pathophysiological mechanisms remain vague. The molecular changes of hippocampal and cortical dysfunction in the process of TBI are poorly understood, especially their chronic effects on metabolic profiles. Here we utilize metabolomics-based liquid chromatography coupled with tandem mass spectrometry coupled with bioinformatics method to assess the perturbation of brain metabolism in rat hippocampus and cortex on day 7. The results revealed a signature panel which...

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Metabolomics Analysis of Hippocampus and Cortex in a Rat Model of Traumatic Brain Injury in the Subacute Phase

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