[Objective]To approach the effect of cold and constraint chronic stress on gastrointestinal function in mice.[Methods]Thirty mice were randomly divided into 2 groups:normal group and model group.Mice in model group were exposed to 16 consecutive days of chronic stress,such as the way of cold-constraint stimulate and abnormal in food intake.General status,gastrointestinal motility,segment pathology and gastrin level were examined.[Results]Animals in model group had no organic lesion in their gastrointestinal tissue,food intake and body weight d...