期刊论文

中文

中国中西医结合消化杂志

1671-038X

2012

20

6

256-259

10.3969/j.issn.1671-038X.2012.06.005

本校为第一机构

[目的]通过观察莪蚕健胃方对胃癌前病变大鼠胃黏膜组织细胞增殖、凋亡及Bcl-2蛋白表达的影响,探讨莪蚕健胃方治疗胃癌前病变的作用机制。[方法]采用N-甲基-N-硝基-N-亚硝基胍（MNNG）配合饥饱失常法诱导造模。设空白对照组,模型对照组,莪蚕健胃方大、中、小剂量组,进行常规病理检测,采用免疫组化SP法、TUNEL法检测胃黏膜组织细胞增殖核抗原（PCNA）、Bcl-2蛋白及凋亡指数（AI）的表达情况。[结果]莪蚕健胃方各剂量组胃黏膜组织病理学变化,中、重度异型增生率与模型对照组相比明显降低（均P〈0.05）;莪蚕健胃方能明显下调胃癌前病变组织细胞的PCNA、Bcl-2的表达,上调AI。[结论]莪蚕健胃方对大鼠实...

[Objective]To investigate the effect of Ecan Jianwei Recipe on the proliferation and apoptosis of mucosa cells in the gastric precancerous lesions of rats. [Methods]The model was es- tablished with N-methyl-N-nitro-N-nitrosoguanidine（MNNG）and irregular diet. All rats were di- vided randomly into blank control group, model group, high-dosage Ecan Jianwei Recipe group, middle-dosage Ecan Jianwei Recipe group and low-dosage Ecan Jianwei Recipe group. Routine pa- thology was examined. The expression of PCNA and Bcl-2 protein and apoptosis index（...